PreprintArticleVersion 1This version is not peer-reviewed
The 2-Hour Plasma Glucose Levels During OGTT, Conducted in the Postprandial Period Between 4 and 7.9 Hours, Are Associated With the Diagnosis of Diabetes, Diabetes Mortality, and Cardiovascular Mortality
Version 1
: Received: 4 July 2024 / Approved: 5 July 2024 / Online: 5 July 2024 (09:49:02 CEST)
How to cite:
Wang, Y.; Fang, Y.; Yang, G. The 2-Hour Plasma Glucose Levels During OGTT, Conducted in the Postprandial Period Between 4 and 7.9 Hours, Are Associated With the Diagnosis of Diabetes, Diabetes Mortality, and Cardiovascular Mortality. Preprints2024, 2024070510. https://doi.org/10.20944/preprints202407.0510.v1
Wang, Y.; Fang, Y.; Yang, G. The 2-Hour Plasma Glucose Levels During OGTT, Conducted in the Postprandial Period Between 4 and 7.9 Hours, Are Associated With the Diagnosis of Diabetes, Diabetes Mortality, and Cardiovascular Mortality. Preprints 2024, 2024070510. https://doi.org/10.20944/preprints202407.0510.v1
Wang, Y.; Fang, Y.; Yang, G. The 2-Hour Plasma Glucose Levels During OGTT, Conducted in the Postprandial Period Between 4 and 7.9 Hours, Are Associated With the Diagnosis of Diabetes, Diabetes Mortality, and Cardiovascular Mortality. Preprints2024, 2024070510. https://doi.org/10.20944/preprints202407.0510.v1
APA Style
Wang, Y., Fang, Y., & Yang, G. (2024). The 2-Hour Plasma Glucose Levels During OGTT, Conducted in the Postprandial Period Between 4 and 7.9 Hours, Are Associated With the Diagnosis of Diabetes, Diabetes Mortality, and Cardiovascular Mortality. Preprints. https://doi.org/10.20944/preprints202407.0510.v1
Chicago/Turabian Style
Wang, Y., Yan Fang and Guang Yang. 2024 "The 2-Hour Plasma Glucose Levels During OGTT, Conducted in the Postprandial Period Between 4 and 7.9 Hours, Are Associated With the Diagnosis of Diabetes, Diabetes Mortality, and Cardiovascular Mortality" Preprints. https://doi.org/10.20944/preprints202407.0510.v1
Abstract
Postprandial plasma glucose between 4 and 7.9 hours is associated with the diagnosis of diabetes, diabetes mortality, and cardiovascular mortality. However, it is unknown whether 2-hour plasma glucose during the oral glucose tolerance test conducted in this postprandial period (4–7.9 hours), termed as 2-h PGOGTT@4–7.9h, can accurately classify diabetes diagnosis and predict mortality risks. This study aimed to address these questions using 2,347 adult participants. Diabetes was defined as HbA1c ≥6.5%, and the ability of 2-h PGOGTT@4–7.9h to classify diabetes was analyzed using receiver operating characteristic curves. Cox proportional hazards models were employed to estimate mortality hazard ratios (HRs) and 95% confidence intervals (CIs). The results showed that 2-h PGOGTT@4–7.9h could classify diabetes with 92% accuracy. Participants were followed up for a mean of 21.4 years. A 1-natural-log higher 2-h PGOGTT@4–7.9h was associated with an increased risk of mortality from diabetes (adjusted HR, 21.1; 95% CI, 9.2–48.0) and cardiovascular disease (adjusted HR, 1.47; 95% CI, 1.13–1.91). Simulation analysis indicated that future studies may require at least 100 participants to investigate 2-h PGOGTT@4–7.9h for diabetes diagnosis. In conclusion, 2-h PGOGTT@4–7.9h may be useful for diabetes classification and prediction of mortality risk.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
