Version 1
: Received: 5 July 2024 / Approved: 5 July 2024 / Online: 8 July 2024 (03:25:35 CEST)
How to cite:
Vlasiou, M. C.; Nikolaou, G.; Spanoudes, K.; Mavrides, D. E. β-tocotrienol and δ-tocotrienol as Additional Inhibitors of the Main Protease of Feline Infectious Peritonitis Virus: An In-Silico Analysis. Preprints2024, 2024070532. https://doi.org/10.20944/preprints202407.0532.v1
Vlasiou, M. C.; Nikolaou, G.; Spanoudes, K.; Mavrides, D. E. β-tocotrienol and δ-tocotrienol as Additional Inhibitors of the Main Protease of Feline Infectious Peritonitis Virus: An In-Silico Analysis. Preprints 2024, 2024070532. https://doi.org/10.20944/preprints202407.0532.v1
Vlasiou, M. C.; Nikolaou, G.; Spanoudes, K.; Mavrides, D. E. β-tocotrienol and δ-tocotrienol as Additional Inhibitors of the Main Protease of Feline Infectious Peritonitis Virus: An In-Silico Analysis. Preprints2024, 2024070532. https://doi.org/10.20944/preprints202407.0532.v1
APA Style
Vlasiou, M. C., Nikolaou, G., Spanoudes, K., & Mavrides, D. E. (2024). <em>β</em>-tocotrienol and <em>δ</em>-tocotrienol as Additional Inhibitors of the Main Protease of Feline Infectious Peritonitis Virus: An In-Silico Analysis. Preprints. https://doi.org/10.20944/preprints202407.0532.v1
Chicago/Turabian Style
Vlasiou, M. C., Kyriakos Spanoudes and Daphne E. Mavrides. 2024 "<em>β</em>-tocotrienol and <em>δ</em>-tocotrienol as Additional Inhibitors of the Main Protease of Feline Infectious Peritonitis Virus: An In-Silico Analysis" Preprints. https://doi.org/10.20944/preprints202407.0532.v1
Abstract
Feline infectious peritonitis (FIP) is a severe and invariably fatal disease affecting both domestic and wild felines with limited effective therapeutic options available. By considering the significant immunomodulatory effects of vitamin E observed in both animal and human models under physiological and pathological conditions, we have provided a full in-silico investigation of vitamin E and related compounds and their effect on the crystal structure of feline infectious peritonitis virus 3C-like protease (FIPV-3CLpro). This work revealed the β-tocotrienol and δ-tocotrienol analogues as inhibitor candidates for this protein, suggesting their potential as possible drug compounds against FIP or their supplementary use with current medicines against this disease.
Keywords
FIP; Vitamin E; inhibitors; drug discovery
Subject
Medicine and Pharmacology, Veterinary Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
