Version 1
: Received: 6 July 2024 / Approved: 7 July 2024 / Online: 8 July 2024 (09:07:13 CEST)
How to cite:
Ba-Hutair, S. N. M.; Dube, R.; Kuruba, M. G. B.; Salama, R. A. A.; Patni, M. M.; Kar, S. S.; Kar, R. Molecular Basis of Hydatidiform Moles – A Systematic Review. Preprints2024, 2024070566. https://doi.org/10.20944/preprints202407.0566.v1
Ba-Hutair, S. N. M.; Dube, R.; Kuruba, M. G. B.; Salama, R. A. A.; Patni, M. M.; Kar, S. S.; Kar, R. Molecular Basis of Hydatidiform Moles – A Systematic Review. Preprints 2024, 2024070566. https://doi.org/10.20944/preprints202407.0566.v1
Ba-Hutair, S. N. M.; Dube, R.; Kuruba, M. G. B.; Salama, R. A. A.; Patni, M. M.; Kar, S. S.; Kar, R. Molecular Basis of Hydatidiform Moles – A Systematic Review. Preprints2024, 2024070566. https://doi.org/10.20944/preprints202407.0566.v1
APA Style
Ba-Hutair, S. N. M., Dube, R., Kuruba, M. G. B., Salama, R. A. A., Patni, M. M., Kar, S. S., & Kar, R. (2024). Molecular Basis of Hydatidiform Moles – A Systematic Review. Preprints. https://doi.org/10.20944/preprints202407.0566.v1
Chicago/Turabian Style
Ba-Hutair, S. N. M., Subhranshu Sekhar Kar and Rakhee Kar. 2024 "Molecular Basis of Hydatidiform Moles – A Systematic Review" Preprints. https://doi.org/10.20944/preprints202407.0566.v1
Abstract
Gestational trophoblastic diseases (GTDs) encompass a spectrum of conditions characterized by abnormal trophoblastic cell growth, ranging from benign molar pregnancies to malignant trophoblastic neoplasms. This systematic review explores the molecular underpinnings of GTDs, focusing on genetic and epigenetic factors that influence disease progression and clinical outcomes. Based on 65 studies identified through systematic search and selection criteria, key findings include dysregulations in tumor suppressor genes such as p53, aberrant apoptotic pathways involving BCL-2, and altered expression of growth factor receptors and microRNAs. These molecular alterations not only differentiate molar pregnancies from normal placental development but also contribute to their clinical behavior, from benign moles to potentially malignant forms. The review synthesizes insights from immunohistochemical studies and molecular analyses to provide a comprehensive understanding of GTD pathogenesis and implications for personalized care strategies.
Medicine and Pharmacology, Obstetrics and Gynaecology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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