Version 1
: Received: 5 July 2024 / Approved: 9 July 2024 / Online: 10 July 2024 (11:54:40 CEST)
How to cite:
JEBARI, N.; Dufour-Gergam, E.; AMMAR, M. 3D Simulation-Driven Design of a Microfluidic Immunosensor for Real-Time Monitoring of Sweat Biomarkers. Preprints2024, 2024070785. https://doi.org/10.20944/preprints202407.0785.v1
JEBARI, N.; Dufour-Gergam, E.; AMMAR, M. 3D Simulation-Driven Design of a Microfluidic Immunosensor for Real-Time Monitoring of Sweat Biomarkers. Preprints 2024, 2024070785. https://doi.org/10.20944/preprints202407.0785.v1
JEBARI, N.; Dufour-Gergam, E.; AMMAR, M. 3D Simulation-Driven Design of a Microfluidic Immunosensor for Real-Time Monitoring of Sweat Biomarkers. Preprints2024, 2024070785. https://doi.org/10.20944/preprints202407.0785.v1
APA Style
JEBARI, N., Dufour-Gergam, E., & AMMAR, M. (2024). 3D Simulation-Driven Design of a Microfluidic Immunosensor for Real-Time Monitoring of Sweat Biomarkers. Preprints. https://doi.org/10.20944/preprints202407.0785.v1
Chicago/Turabian Style
JEBARI, N., Elisabeth Dufour-Gergam and Mehdi AMMAR. 2024 "3D Simulation-Driven Design of a Microfluidic Immunosensor for Real-Time Monitoring of Sweat Biomarkers" Preprints. https://doi.org/10.20944/preprints202407.0785.v1
Abstract
This study presents the design and comprehensive 3D multiphysics simulation of a novel microfluidic immunosensor for real-time, non-invasive monitoring of pro-inflammatory biomarkers in human sweat. The patch-like device, designed using COMSOL Multiphysics, integrates magnetofluidic manipulation with direct-field capacitive sensing. The sensor comprises two distinct units: an immunocomplex enhancement unit, employing a series of microcoils to optimize the binding efficiency, reaction kinetics, and homogeneity of biomarker-magnetic nanoparticle (MNP) interactions, thereby enhancing the sensor's specificity; and a layered capacitive sensing unit, designed to concentrate and detect biomarker-tagged MNPs, thus amplifying sensitivity. Simulations of the capacitive sensing unit revealed a substantial sensitivity increase of up to 42.48\% at an 85\% MNP concentration within the detection zone. These findings highlight the potential of the proposed immunosensor for efficient and precise real-time biomarker monitoring, which may facilitate early disease diagnosis and enable personalized healthcare interventions.
Keywords
microfluidic immunosensor; 3D simulation; capacitive sensing; magnetofluidic manipulation; real-time monitoring
Subject
Engineering, Bioengineering
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
