Preprint Review Version 1 This version is not peer-reviewed

Forging the Iron-Net: Towards a Quantitative Understanding of Microbial Communities via Siderophore-Mediated Interactions

Shaohua Gu
,
Ruolin He
,
Guanyue Xiong
,
Zeyang Qu
,
Yuanzhe Shao
,
Linlong Yu
,
Di Zhang
,
Fanhao Wang
,
Ruichen Xu
,
Peng Guo
,
Ningbo Xi
,
Yinxiang Li
,
Yanzhao Wu
,
Zhong Wei
,
Zhiyuan Li
*
Version 1 : Received: 10 July 2024 / Approved: 10 July 2024 / Online: 11 July 2024 (09:59:13 CEST)

How to cite: Gu, S.; He, R.; Xiong, G.; Qu, Z.; Shao, Y.; Yu, L.; Zhang, D.; Wang, F.; Xu, R.; Guo, P.; Xi, N.; Li, Y.; Wu, Y.; Wei, Z.; Li, Z. Forging the Iron-Net: Towards a Quantitative Understanding of Microbial Communities via Siderophore-Mediated Interactions. Preprints 2024, 2024070834. https://doi.org/10.20944/preprints202407.0834.v1 Gu, S.; He, R.; Xiong, G.; Qu, Z.; Shao, Y.; Yu, L.; Zhang, D.; Wang, F.; Xu, R.; Guo, P.; Xi, N.; Li, Y.; Wu, Y.; Wei, Z.; Li, Z. Forging the Iron-Net: Towards a Quantitative Understanding of Microbial Communities via Siderophore-Mediated Interactions. Preprints 2024, 2024070834. https://doi.org/10.20944/preprints202407.0834.v1

Abstract

Iron is a critical yet limited nutrient for microbial growth. To scavenge iron, most microbes produce siderophores—diverse small molecules with high iron affinities. Different siderophores are specifically recognized and uptaken by corresponding recognizers, enabling targeted interventions and intriguing cheater-producer dynamics. We propose constructing a comprehensive iron interaction network, or "iron-net," across the microbial world. Such a network offers the potential for precise manipulation of the microbiota, with conceivable applications in medicine, agriculture, and industry, as well as advancing microbial ecology and evolution theories. Previously, our successful construction of an iron-net in the Pseudomonas genus demonstrated the feasibility of co-evolution-inspired digital siderophore typing. Enhanced by machine learning techniques and expanding sequencing data, forging such an iron-net calls for multidisciplinary collaborations, and holds significant promise in addressing critical challenges in microbial communities.

Keywords

iron-net; siderophores; microbial community; ecology; evolution

Subject

Biology and Life Sciences, Ecology, Evolution, Behavior and Systematics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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