Synthesis, Characterization, and Docking Study of a Novel Indole Derivative Containing a Tosyl Moiety as Anti-oxidant Agent

Abdelali Chihab; Nabil El Brahmi; Saïd El Kazzouli

doi:10.20944/preprints202407.0909.v1

Preprint Communication Version 1 This version is not peer-reviewed

Version 1 : Received: 10 July 2024 / Approved: 11 July 2024 / Online: 11 July 2024 (12:41:11 CEST)

Indole derivatives are key components of natural products and possesses a wide range of biological and pharmaceutical applications. Here we present the synthesis of a new indole derivative namely 2-(1-ethyl-5-nitro-1H-indole-7-carbonyl) butyl 4-methylbenzenesulfonate (5). The structural elucidation of 5 was accomplished through comprehensive spectroscopic analysis, including Fourier-transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), and high-resolution mass spectrometry (HRMS). Our molecular docking study revealed that compound 5 exhibits strong affinity towards Tyrosinase, making it a promising candidate as an antioxidant agent. Keywords: Indole derivative; Tosyl group; Molecular docking; Antioxidant agent.

Indoles; sulfonamides; Molecular docking; Tyrosinase; Antioxidant

Chemistry and Materials Science, Medicinal Chemistry

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Synthesis, Characterization, and Docking Study of a Novel Indole Derivative Containing a Tosyl Moiety as Anti-oxidant Agent

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