Version 1
: Received: 11 July 2024 / Approved: 11 July 2024 / Online: 12 July 2024 (09:39:49 CEST)
How to cite:
Marinova, P. E.; Stoitsov, D. G.; Burdzhiev, N. T.; Tsoneva, S. H.; Blazheva, D. E.; Slavchev, A. K.; Varbanova, E. K.; Penchev, P. N. Synthesis and Biological Study of New Cu(II) and Au(III) Com-Plexes of 2,4-Dithiouracil and Its Derivatives. Preprints2024, 2024070929. https://doi.org/10.20944/preprints202407.0929.v1
Marinova, P. E.; Stoitsov, D. G.; Burdzhiev, N. T.; Tsoneva, S. H.; Blazheva, D. E.; Slavchev, A. K.; Varbanova, E. K.; Penchev, P. N. Synthesis and Biological Study of New Cu(II) and Au(III) Com-Plexes of 2,4-Dithiouracil and Its Derivatives. Preprints 2024, 2024070929. https://doi.org/10.20944/preprints202407.0929.v1
Marinova, P. E.; Stoitsov, D. G.; Burdzhiev, N. T.; Tsoneva, S. H.; Blazheva, D. E.; Slavchev, A. K.; Varbanova, E. K.; Penchev, P. N. Synthesis and Biological Study of New Cu(II) and Au(III) Com-Plexes of 2,4-Dithiouracil and Its Derivatives. Preprints2024, 2024070929. https://doi.org/10.20944/preprints202407.0929.v1
APA Style
Marinova, P. E., Stoitsov, D. G., Burdzhiev, N. T., Tsoneva, S. H., Blazheva, D. E., Slavchev, A. K., Varbanova, E. K., & Penchev, P. N. (2024). Synthesis and Biological Study of New Cu(II) and Au(III) Com-Plexes of 2,4-Dithiouracil and Its Derivatives. Preprints. https://doi.org/10.20944/preprints202407.0929.v1
Chicago/Turabian Style
Marinova, P. E., Evelina Konstantinova Varbanova and Plamen Nikolov Penchev. 2024 "Synthesis and Biological Study of New Cu(II) and Au(III) Com-Plexes of 2,4-Dithiouracil and Its Derivatives" Preprints. https://doi.org/10.20944/preprints202407.0929.v1
Abstract
The goal of this study is to synthesize, determine the structure, and examine the antimicrobial properties of novel metal complexes of 2,4-dithiouracil and its derivatives. These complexes were obtained by mixing aqueous solutions of the corresponding metal salts with the ligand dissolved in DMSO and aqueous NaOH, using a metal-to-ligand ratio of 1:4:2. The structures of the new compounds were analyzed by melting point determination, microwave plasma atomic emission spectrometry (MP-AES) for Cu and Au, inductively coupled plasma optical emission spectrometry (ICP-OES) for S, ATR, solution and solid-state NMR and Raman spectroscopy. The interpretation of the complex spectra was aided by data for 2,4-dithiouracil obtained from 1H-1H COSY, DEPT-135, HMBC, and HMQC spectra. Additionally, the antimicrobial activity of these complex-es and the free ligands was evaluated against Gram-positive and Gram-negative bacteria, as well as yeasts.
Chemistry and Materials Science, Inorganic and Nuclear Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
