PreprintArticleVersion 1This version is not peer-reviewed
Progressive Keratoconus Treatment with Transepithelial 2-Step Phototherapeutic Keratectomy Combined with Corneal Cross-Linking (CXL): Clinical Outcomes and Postoperative Management including Potential Complications, of the Modified Athens Protocol De
Version 1
: Received: 15 July 2024 / Approved: 15 July 2024 / Online: 15 July 2024 (11:34:58 CEST)
How to cite:
Kanellopoulos, A. J.; Kanellopoulos, A. J. Progressive Keratoconus Treatment with Transepithelial 2-Step Phototherapeutic Keratectomy Combined with Corneal Cross-Linking (CXL): Clinical Outcomes and Postoperative Management including Potential Complications, of the Modified Athens Protocol De. Preprints2024, 2024071159. https://doi.org/10.20944/preprints202407.1159.v1
Kanellopoulos, A. J.; Kanellopoulos, A. J. Progressive Keratoconus Treatment with Transepithelial 2-Step Phototherapeutic Keratectomy Combined with Corneal Cross-Linking (CXL): Clinical Outcomes and Postoperative Management including Potential Complications, of the Modified Athens Protocol De. Preprints 2024, 2024071159. https://doi.org/10.20944/preprints202407.1159.v1
Kanellopoulos, A. J.; Kanellopoulos, A. J. Progressive Keratoconus Treatment with Transepithelial 2-Step Phototherapeutic Keratectomy Combined with Corneal Cross-Linking (CXL): Clinical Outcomes and Postoperative Management including Potential Complications, of the Modified Athens Protocol De. Preprints2024, 2024071159. https://doi.org/10.20944/preprints202407.1159.v1
APA Style
Kanellopoulos, A. J., & Kanellopoulos, A. J. (2024). Progressive Keratoconus Treatment with Transepithelial 2-Step Phototherapeutic Keratectomy Combined with Corneal Cross-Linking (CXL): Clinical Outcomes and Postoperative Management including Potential Complications, of the Modified Athens Protocol De. Preprints. https://doi.org/10.20944/preprints202407.1159.v1
Chicago/Turabian Style
Kanellopoulos, A. J. and Alexander J. Kanellopoulos. 2024 "Progressive Keratoconus Treatment with Transepithelial 2-Step Phototherapeutic Keratectomy Combined with Corneal Cross-Linking (CXL): Clinical Outcomes and Postoperative Management including Potential Complications, of the Modified Athens Protocol De" Preprints. https://doi.org/10.20944/preprints202407.1159.v1
Abstract
ABSTRACT
Purpose: To report a novel application of excimer ablation for normalization of central corneal refractive irregularity, combined with higher fluence CXL in the effective management and visual rehabilitation of progressive keratoconus. Methods: 17 cases with progressive keratoconus were treated with a corneal surface excimer laser ablation normalization using the topography-guided (Contura) myopic ablation for customized corneal re-shaping using a 6mm optical zone. The epi-thelial removal was accounted for by adding a -2.75 diopters correction in the topography-guided normalizing surface ablation followed by, a second, wavefront-optimized hyperopic excimer treatment of + 2.75 diopters at 6mm optical zone. The 2 sequential excimer ablations were fol-lowed by the corneal crosslinking (CXL). Visual acuity, refraction, and keratoconus documentation via keratometry, topography, and pachymetry, as well as endothelial cell density were evaluated over 36 months. Results: Keratoconus stabilized in all cases. The severity of keratoconus stage by Amsler-Krumeich criteria improved for the OD from an average 2.2 to 1. Mean UDVA showed marked improvement at one-year follow-up all values in decimal: from 0.21±0.18 pre-operative to 0.51±0.25 at 12 months, with small additional improvement through the 3 years to 0.51±0.16. CDVA respectively increased from 0.55±0.11 to 0.77±0.14 at 1 year, and to 0.79±0.16 at 3 years. Mean minimal corneal thickness decreased significantly from 466.74±34.25 μm to 396.17±45.17 μm (P
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
