Version 1
: Received: 12 July 2024 / Approved: 15 July 2024 / Online: 15 July 2024 (13:41:31 CEST)
How to cite:
Vatté, J.; Bourdeau, V.; Ferbeyre, G.; Schmitzer, A. Gaining Insight into Mitochondrial Targeting: AUTAC-Biguanide as an Anticancer Agent. Preprints2024, 2024071193. https://doi.org/10.20944/preprints202407.1193.v1
Vatté, J.; Bourdeau, V.; Ferbeyre, G.; Schmitzer, A. Gaining Insight into Mitochondrial Targeting: AUTAC-Biguanide as an Anticancer Agent. Preprints 2024, 2024071193. https://doi.org/10.20944/preprints202407.1193.v1
Vatté, J.; Bourdeau, V.; Ferbeyre, G.; Schmitzer, A. Gaining Insight into Mitochondrial Targeting: AUTAC-Biguanide as an Anticancer Agent. Preprints2024, 2024071193. https://doi.org/10.20944/preprints202407.1193.v1
APA Style
Vatté, J., Bourdeau, V., Ferbeyre, G., & Schmitzer, A. (2024). Gaining Insight into Mitochondrial Targeting: AUTAC-Biguanide as an Anticancer Agent. Preprints. https://doi.org/10.20944/preprints202407.1193.v1
Chicago/Turabian Style
Vatté, J., Gerardo Ferbeyre and Andreea Schmitzer. 2024 "Gaining Insight into Mitochondrial Targeting: AUTAC-Biguanide as an Anticancer Agent" Preprints. https://doi.org/10.20944/preprints202407.1193.v1
Abstract
AUTAC-Biguanide is a hybrid compound designed to target mitochondria inducing their degradation by mitophagy. This study unveils the potential of biguanides as cancer cell-targeting agents, emphasizing AUTAC-Biguanide's superior antiproliferative properties compared to metformin and its selectivity for cancer cells. The mechanism behind this heightened effect includes the ability of AUTAC-Biguanide to triggers mitophagy. By providing a comprehensive analysis of these findings, the study adds valuable insights to the field of mitochondrial-targeting anticancer agents.
Keywords
AUTAC; biguanide; pancreatic cancer
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.