Preprint Article Version 1 This version is not peer-reviewed

Comparative Analysis of Comprehensive Genomic Profile in Thymomas and Recurrent Thymomas Reveals Potentially Actionable Mutations for Target Therapies

Version 1 : Received: 16 July 2024 / Approved: 16 July 2024 / Online: 17 July 2024 (11:00:23 CEST)

How to cite: Lococo, F.; De Paolis, E.; Evangelista, J.; Dell’Amore, A.; Giannarelli, D.; Chiappetta, M.; Campanella, A.; Sassorossi, C.; Cancellieri, A.; Calabrese, F.; Vita, E.; Minucci, A.; Bria, E.; Castello, A.; Urbani, A.; Rea, F.; Margaritora, S.; Scambia, G. Comparative Analysis of Comprehensive Genomic Profile in Thymomas and Recurrent Thymomas Reveals Potentially Actionable Mutations for Target Therapies. Preprints 2024, 2024071356. https://doi.org/10.20944/preprints202407.1356.v1 Lococo, F.; De Paolis, E.; Evangelista, J.; Dell’Amore, A.; Giannarelli, D.; Chiappetta, M.; Campanella, A.; Sassorossi, C.; Cancellieri, A.; Calabrese, F.; Vita, E.; Minucci, A.; Bria, E.; Castello, A.; Urbani, A.; Rea, F.; Margaritora, S.; Scambia, G. Comparative Analysis of Comprehensive Genomic Profile in Thymomas and Recurrent Thymomas Reveals Potentially Actionable Mutations for Target Therapies. Preprints 2024, 2024071356. https://doi.org/10.20944/preprints202407.1356.v1

Abstract

Conclusions: CGP do not substantially differ between initial tumor vs tumor recurrence and recurrent thymomas vs non-recurrent thymomas. Cell-cycle control genes alterations are associated with an early recurrence after thymectomy. Multiple target therapies are potentially available by performing a comprehensive CGP, suggesting that a precision medicine approach on these patients could be further explored.

Keywords

NGS; recurrent thymoma; surgery; CGP; gene profile; clinical trials

Subject

Medicine and Pharmacology, Oncology and Oncogenics

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