Review
Version 1
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Overview of the Multifaceted Functions of LncRNA HOTAIR in Glioblastoma
Version 1
: Received: 16 July 2024 / Approved: 17 July 2024 / Online: 17 July 2024 (12:40:12 CEST)
How to cite: Azab, M. A. Overview of the Multifaceted Functions of LncRNA HOTAIR in Glioblastoma. Preprints 2024, 2024071411. https://doi.org/10.20944/preprints202407.1411.v1 Azab, M. A. Overview of the Multifaceted Functions of LncRNA HOTAIR in Glioblastoma. Preprints 2024, 2024071411. https://doi.org/10.20944/preprints202407.1411.v1
Abstract
Glioblastoma is a highly aggressive brain tumor and is considered to be the most common primary one. Recurrence after treatment is a major problem. The recurrence of GBM is related to different cellular mechanisms and molecular signaling. Therapies to prolong survival are not completely effective. Epigenetics and non-coding genetic elements play a crucial role in gliomagenesis. Non-coding RNAs are novel regulatory RNAs that play key roles in different physiological processes such as gene regulation, cell differentiation, and proliferation. Interestingly, some LncRNAs have a tumor suppressor role while others are oncogenic. In this review article, we are going to illustrate the role of a well-known lncRNA HOX transcript antisense intergenic RNA (HOTAIR) in glioma and highlight the possible functions in glioma in both pre-clinical and clinically evident studies.
Keywords
HOTAIR; ncRNAs; GBM; high grade glioma; epigenetics
Subject
Biology and Life Sciences, Neuroscience and Neurology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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