Preprint Article Version 1 This version is not peer-reviewed

Differences in Prevalence of Colorectal Carcinoma by Gender and Marital Status and Expression of DNA Mismatch Repair Proteins

Version 1 : Received: 17 July 2024 / Approved: 18 July 2024 / Online: 18 July 2024 (09:57:13 CEST)

How to cite: Zhang, P.; Bakhtar, O.; Wixom, C.; Cox, B.; Lee, J.; Sadeghi, S.; Clement, A.; Kabakibi, L.; Schwab, M. Differences in Prevalence of Colorectal Carcinoma by Gender and Marital Status and Expression of DNA Mismatch Repair Proteins. Preprints 2024, 2024071460. https://doi.org/10.20944/preprints202407.1460.v1 Zhang, P.; Bakhtar, O.; Wixom, C.; Cox, B.; Lee, J.; Sadeghi, S.; Clement, A.; Kabakibi, L.; Schwab, M. Differences in Prevalence of Colorectal Carcinoma by Gender and Marital Status and Expression of DNA Mismatch Repair Proteins. Preprints 2024, 2024071460. https://doi.org/10.20944/preprints202407.1460.v1

Abstract

Background: Gender dimorphism and marital status on colorectal cancer mortality have been previously documented, but the relationship between these factors and DNA mismatch repair protein (MMRP) expression status is unknown. Methods: Colectomy specimens were reviewed retrospectively for patients between 2018 to 2023 with demographics including race/ethnicity, gender, marital status, faith, body mass index, pathologic staging, and MMRP expression status. Statistical analyses were performed by using baseline characteristics tables and various programs in R-package. Results: A total 1018 colectomies were reviewed, and the tumor stages were significantly higher in right colon (stage 3 and 4) than those in left colon and rectosigmoid colon (p

Keywords

Colorectal Cancer, DNA Mismatch repair enzyme, Gender and Marital status

Subject

Medicine and Pharmacology, Oncology and Oncogenics

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