Version 1
: Received: 18 July 2024 / Approved: 18 July 2024 / Online: 19 July 2024 (02:26:26 CEST)
How to cite:
Liu, J.; Zhao, F.; Qu, Y. Lactylation: A Novel Post-Translational Modification with Clinical Implications in CNS Diseases. Preprints2024, 2024071493. https://doi.org/10.20944/preprints202407.1493.v1
Liu, J.; Zhao, F.; Qu, Y. Lactylation: A Novel Post-Translational Modification with Clinical Implications in CNS Diseases. Preprints 2024, 2024071493. https://doi.org/10.20944/preprints202407.1493.v1
Liu, J.; Zhao, F.; Qu, Y. Lactylation: A Novel Post-Translational Modification with Clinical Implications in CNS Diseases. Preprints2024, 2024071493. https://doi.org/10.20944/preprints202407.1493.v1
APA Style
Liu, J., Zhao, F., & Qu, Y. (2024). Lactylation: A Novel Post-Translational Modification with Clinical Implications in CNS Diseases. Preprints. https://doi.org/10.20944/preprints202407.1493.v1
Chicago/Turabian Style
Liu, J., Fengyan Zhao and Yi Qu. 2024 "Lactylation: A Novel Post-Translational Modification with Clinical Implications in CNS Diseases" Preprints. https://doi.org/10.20944/preprints202407.1493.v1
Abstract
Lactate, an important metabolic product, provides energy to neural cells during energy depletion or high demand and acts as a signaling molecule in the central nervous system. Recent studies revealed that lactate-mediated protein lactylation regulates gene transcription and influences cell fate, metabolic processes, inflammation, and immune responses. This review comprehensively examines the regulatory roles and mechanisms of lactylation in neurodevelopment, neuropsychiatric disorders, brain tumors, and cerebrovascular diseases. This analysis indicates that lactylation has multifaceted effects on central nervous system function and pathology, particularly in hypoxia-induced brain damage. Highlighting its potential as a novel therapeutic target, lactylation may play a significant role in treating neurological diseases. By summarizing current findings, this review aims to provide insights and guide future research and clinical strategies for central nervous system disorders.
Keywords
lactylation; epigenetics; neurodevelopment; central nervous system diseases; therapeutic target
Subject
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
