Tsuji, T.; Furuhara, K.; Guo, E.; Wu, Y.; Zhong, J.; Higashida, H.; Yamamoto, Y.; Tsuji, C. Oral Supplementation of L-Carnosine Attenuates Acute Stress-Induced Corticosterone Release and Mitigates Anxiety in CD157 Knockout Mice. Preprints2024, 2024071621. https://doi.org/10.20944/preprints202407.1621.v1
APA Style
Tsuji, T., Furuhara, K., Guo, E., Wu, Y., Zhong, J., Higashida, H., Yamamoto, Y., & Tsuji, C. (2024). Oral Supplementation of L-Carnosine Attenuates Acute Stress-Induced Corticosterone Release and Mitigates Anxiety in CD157 Knockout Mice. Preprints. https://doi.org/10.20944/preprints202407.1621.v1
Chicago/Turabian Style
Tsuji, T., Yasuhiko Yamamoto and Chiharu Tsuji. 2024 "Oral Supplementation of L-Carnosine Attenuates Acute Stress-Induced Corticosterone Release and Mitigates Anxiety in CD157 Knockout Mice" Preprints. https://doi.org/10.20944/preprints202407.1621.v1
Abstract
Corticosterone, an end product of the hypothalamic-pituitary-adrenal (HPA) axis, is a crucial stress hormone. Dysregulated HPA axis and corticosterone release play pivotal roles in the onset and persistence of symptoms of stress-related psychiatric disorders such as anxiety. The intake of nutrients, probiotics, and prebiotic supplements decreases blood corticosterone levels. The dipeptide L-carnosine is composed of beta-alanine and L-histidine and is commercially available as a nutritional supplement for recovery from fatigue. L-carnosine is involved in stress-induced corticosterone responses and anxiety behaviors in rodents. Here, we assessed the effect of L-carnosine in CD157 knockout (KO) mice, a murine model of autism spectrum disorder (ASD). The uptake of L-carnosine suppressed the increase in plasma corticosterone levels in response to acute stress and attenuated anxiety-like behaviors in CD157 KO mice. These results suggest that L-carnosine supplementation may relieve anxiety by suppressing excessive stress responses in individuals with ASD.
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