PreprintArticleVersion 1This version is not peer-reviewed
Diversity, Distribution, and Resistance Profiles of Bacterial Bloodstream Infections in Three Tertiary Referral Hospitals in Rwanda between 2020 and 2022
Version 1
: Received: 20 July 2024 / Approved: 20 July 2024 / Online: 22 July 2024 (09:41:09 CEST)
How to cite:
Gashegu, M.; Ndahindwa, V.; Rwagasore, E.; Tuyishime, A.; Musanabaganwa, C.; Gahamanyi, N.; Mukagatare, I.; Mbarushimana, D.; Green, C. A.; Dzinamarira, T.; Ahmed, A.; Muvunyi, C. M. Diversity, Distribution, and Resistance Profiles of Bacterial Bloodstream Infections in Three Tertiary Referral Hospitals in Rwanda between 2020 and 2022. Preprints2024, 2024071643. https://doi.org/10.20944/preprints202407.1643.v1
Gashegu, M.; Ndahindwa, V.; Rwagasore, E.; Tuyishime, A.; Musanabaganwa, C.; Gahamanyi, N.; Mukagatare, I.; Mbarushimana, D.; Green, C. A.; Dzinamarira, T.; Ahmed, A.; Muvunyi, C. M. Diversity, Distribution, and Resistance Profiles of Bacterial Bloodstream Infections in Three Tertiary Referral Hospitals in Rwanda between 2020 and 2022. Preprints 2024, 2024071643. https://doi.org/10.20944/preprints202407.1643.v1
Gashegu, M.; Ndahindwa, V.; Rwagasore, E.; Tuyishime, A.; Musanabaganwa, C.; Gahamanyi, N.; Mukagatare, I.; Mbarushimana, D.; Green, C. A.; Dzinamarira, T.; Ahmed, A.; Muvunyi, C. M. Diversity, Distribution, and Resistance Profiles of Bacterial Bloodstream Infections in Three Tertiary Referral Hospitals in Rwanda between 2020 and 2022. Preprints2024, 2024071643. https://doi.org/10.20944/preprints202407.1643.v1
APA Style
Gashegu, M., Ndahindwa, V., Rwagasore, E., Tuyishime, A., Musanabaganwa, C., Gahamanyi, N., Mukagatare, I., Mbarushimana, D., Green, C. A., Dzinamarira, T., Ahmed, A., & Muvunyi, C. M. (2024). Diversity, Distribution, and Resistance Profiles of Bacterial Bloodstream Infections in Three Tertiary Referral Hospitals in Rwanda between 2020 and 2022. Preprints. https://doi.org/10.20944/preprints202407.1643.v1
Chicago/Turabian Style
Gashegu, M., Ayman Ahmed and Claude Mambo Muvunyi. 2024 "Diversity, Distribution, and Resistance Profiles of Bacterial Bloodstream Infections in Three Tertiary Referral Hospitals in Rwanda between 2020 and 2022" Preprints. https://doi.org/10.20944/preprints202407.1643.v1
Abstract
The burden of bacterial bloodstream infections (BSIs) is rapidly increasing in Africa including Rwanda. This is a retrospective study investigates the diversity, distribution, and antimicrobial susceptibility profiles of BSIs bacteria in three tertiary referral hospitals in Rwanda between 2020 and 2022. A total of 1,532 blood culture tests were performed for visiting patients. Overall, the proportions of Gram-negative and Gram-positive bacteria were 48.2% and 51.8, respectively. Staphylococcus aureus was the predominant species accounting for 25% of all Gram-positive BSIs species and Klebsiella species representing 41% of all Gram-negative BSIs species. Antimicrobial susceptibility testing revealed that Amikacin exhibited the highest activity against Enterobacter spp., Serratia spp. and Escherichia coli in >92% of cases and Klebsiella spp. in 75.7%. Meropenem and Imipenem were highly efficacious to Salmonella spp. (100% susceptibility), Enterobacter spp. (96.2% and 91.7%, respectively), and Escherichia coli (94.7% and 95.5%, respectively). The susceptibility of Enterococcus spp., S. aureus, and Streptococcus spp. to Vancomycin was 100%, 99.5% and 97.1%, respectively. Klebsiella spp. was highly sensitive to Colistin (98.7%), Polymyxin B (85.6%), Imipenem (84.9%), and Meropenem (78.5%). We recommend strengthening the implementation of integrated transdisciplinary and multisectoral One Health including AMR-stewardship for the surveillance, prevention, and control of AMR in Rwanda.
Keywords
Integrated transdisciplinary multisectoral One Health Strategy; AMR stewardship; Gram-negative Bacteria; Gram-positive Bacteria; health facility-acquired infection
Subject
Public Health and Healthcare, Public, Environmental and Occupational Health
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
