Version 1
: Received: 19 July 2024 / Approved: 22 July 2024 / Online: 22 July 2024 (07:45:34 CEST)
How to cite:
Soto, M. E.; Manzano-Pech, L.; Guarner-Lans, V.; Rodriguez Zanella, H.; Pérez-Torres, I. Oxidative Stress in Aortic Valves Associated with Infective Endocarditis: Series of Three Cases. Preprints2024, 2024071675. https://doi.org/10.20944/preprints202407.1675.v1
Soto, M. E.; Manzano-Pech, L.; Guarner-Lans, V.; Rodriguez Zanella, H.; Pérez-Torres, I. Oxidative Stress in Aortic Valves Associated with Infective Endocarditis: Series of Three Cases. Preprints 2024, 2024071675. https://doi.org/10.20944/preprints202407.1675.v1
Soto, M. E.; Manzano-Pech, L.; Guarner-Lans, V.; Rodriguez Zanella, H.; Pérez-Torres, I. Oxidative Stress in Aortic Valves Associated with Infective Endocarditis: Series of Three Cases. Preprints2024, 2024071675. https://doi.org/10.20944/preprints202407.1675.v1
APA Style
Soto, M. E., Manzano-Pech, L., Guarner-Lans, V., Rodriguez Zanella, H., & Pérez-Torres, I. (2024). Oxidative Stress in Aortic Valves Associated with Infective Endocarditis: Series of Three Cases. Preprints. https://doi.org/10.20944/preprints202407.1675.v1
Chicago/Turabian Style
Soto, M. E., Hugo Rodriguez Zanella and Israel Pérez-Torres. 2024 "Oxidative Stress in Aortic Valves Associated with Infective Endocarditis: Series of Three Cases" Preprints. https://doi.org/10.20944/preprints202407.1675.v1
Abstract
Background: Infective endocarditis (IE) is the result of infections by gram-positive bacteria and, in this condition, the redox homeostasis is lost by overproduction of H2O2 resulting in overstimulation of the immune system and up- regulation of the production of proinflammatory cytokines. Objectives: The aim of this preliminary study of three cases with IE, was to evaluate the levels of oxidative biomarkers and of the enzymatic and non-enzymatic antioxidant system, in subjects with IE. This is a preliminary retrospective analytical study of cases that had undergone aortic valve replacement surgery complicated by IE. Methods: We determined malondialdehyde (MDA), total antioxidant capacity (TAC), carbonyl groups, glutathione (GSH), thiols and the nitrate/nitrite ratio (NO3−/NO2−) in homogenized tissue of cardiac valves. We also measured the activities of GST, GPx, GR and TrxR. The super oxide dismutase (SOD) isoforms and peroxidase activities were determined using native gels. Results: There were increases in the activities of antioxidant enzymes such as GST, SOD isoforms and peroxidases (p=0.01) and decreases in OS markers such as GSH, TAC, (p=0.01); however, MDA was increased (p=0.01). Conclusions: The results suggest that there is loss of the intricate redox homeostasis system in the patients with EI in the aortic valve may be favors the bacterial process and damages the patient probably leading to a fatal outcome.
Medicine and Pharmacology, Cardiac and Cardiovascular Systems
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
