Version 1
: Received: 21 July 2024 / Approved: 22 July 2024 / Online: 23 July 2024 (07:25:20 CEST)
How to cite:
Fri, J.; Raphalalani, M.; Mavhandu-Ramarumo, L. G.; Bessong, P. O. Exploring the Potential Influence of Human Gut Microbiota on Gut Resistome: A Systematic Review. Preprints2024, 2024071742. https://doi.org/10.20944/preprints202407.1742.v1
Fri, J.; Raphalalani, M.; Mavhandu-Ramarumo, L. G.; Bessong, P. O. Exploring the Potential Influence of Human Gut Microbiota on Gut Resistome: A Systematic Review. Preprints 2024, 2024071742. https://doi.org/10.20944/preprints202407.1742.v1
Fri, J.; Raphalalani, M.; Mavhandu-Ramarumo, L. G.; Bessong, P. O. Exploring the Potential Influence of Human Gut Microbiota on Gut Resistome: A Systematic Review. Preprints2024, 2024071742. https://doi.org/10.20944/preprints202407.1742.v1
APA Style
Fri, J., Raphalalani, M., Mavhandu-Ramarumo, L. G., & Bessong, P. O. (2024). Exploring the Potential Influence of Human Gut Microbiota on Gut Resistome: A Systematic Review. Preprints. https://doi.org/10.20944/preprints202407.1742.v1
Chicago/Turabian Style
Fri, J., Lufuno Grace Mavhandu-Ramarumo and Pascal Obong Bessong. 2024 "Exploring the Potential Influence of Human Gut Microbiota on Gut Resistome: A Systematic Review" Preprints. https://doi.org/10.20944/preprints202407.1742.v1
Abstract
Antibiotic resistance is a global health problem. The human gut microbiome is implicated in the dynamics of antibiotic resistance acquisition and transmission, with the gut microbiota thought to play a crucial role. This study aimed to determine the potential influence of human gut bacteria microbiota on the gut resistome and the relationship between gut background microbiota and Escherichia coli resistome. The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines was used to systematically review studies that characterised gut microbiota and resistome using metagenomic analysis and/or those that reported gut E. coli resistome in healthy individuals. Changes in the diversity and abundance of bacterial gut microbiota and the resistome across different groups and the microbiota composition of the gut harbouring antibiotic-resistant E. coli were summarised. Findings suggest that lower bacterial microbiota diversity is likely associated with an increased abundance of the overall gut resistome. Age-related differences were observed, with younger infants exhibiting lower microbiota diversity and higher ARG abundance compared to older infants and adults. Studies that reported correlation revealed positive correlations between the compositional relative abundance of Proteobacteria and ARGs abundance, mainly driven by members within the Enterobacteriaceae family, particularly E. coli. This study also revealed that human gut microbiome studies that investigate gut resistome using metagenomic sequencing approaches in apparently healthy individuals are at least uncommon.
Keywords
Gut microbiota; Gut resistome; Antibiotic resistance genes; Escherichia coli
Subject
Biology and Life Sciences, Immunology and Microbiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
