Version 1
: Received: 22 July 2024 / Approved: 23 July 2024 / Online: 23 July 2024 (13:21:38 CEST)
How to cite:
Butauskaite, J.; Zumbakyte, A.; Aukstikalne, L.; Pancere, J.; Zukaitiene, S.; Karinauske, E. Investigation of the Prevalence of Drug-Drug Interactions in the Cardiology Department. Preprints2024, 2024071780. https://doi.org/10.20944/preprints202407.1780.v1
Butauskaite, J.; Zumbakyte, A.; Aukstikalne, L.; Pancere, J.; Zukaitiene, S.; Karinauske, E. Investigation of the Prevalence of Drug-Drug Interactions in the Cardiology Department. Preprints 2024, 2024071780. https://doi.org/10.20944/preprints202407.1780.v1
Butauskaite, J.; Zumbakyte, A.; Aukstikalne, L.; Pancere, J.; Zukaitiene, S.; Karinauske, E. Investigation of the Prevalence of Drug-Drug Interactions in the Cardiology Department. Preprints2024, 2024071780. https://doi.org/10.20944/preprints202407.1780.v1
APA Style
Butauskaite, J., Zumbakyte, A., Aukstikalne, L., Pancere, J., Zukaitiene, S., & Karinauske, E. (2024). Investigation of the Prevalence of Drug-Drug Interactions in the Cardiology Department. Preprints. https://doi.org/10.20944/preprints202407.1780.v1
Chicago/Turabian Style
Butauskaite, J., Skaiste Zukaitiene and Egle Karinauske. 2024 "Investigation of the Prevalence of Drug-Drug Interactions in the Cardiology Department" Preprints. https://doi.org/10.20944/preprints202407.1780.v1
Abstract
With increasing numbers of older adults worldwide, multimorbidity and polypharmacy are on the rise, highlighting the risks of harmful drug-drug interactions (DDIs) to patients. As cardiovascular agents are among the most prescribed medications, we performed an observational cross-sectional study to determine the prevalence of DDIs in a cardiology department of a secondary hospital. Patient data was obtained from medical records and screened for DDIs using the Micromedex drug interaction software. Descriptive statistics, Chi-square (χ2) test, Student's t test and Pearson's correlation test were used to analyse the results. Out of 50 participants, 45 (90%) had at least one DDI. A total of 266 DDIs were identified, with more than half classified as major. At least one major DDI was found in 78% of patients. 42% of patients were at an increased risk of bleeding due to DDIs. A statistically significant relationship was found between the detection of DDIs and both patient age (p = 0.005) and the number of drugs used (p < 0.001). Our findings pose questions about the wider prevalence and risks of drug-drug interactions among patients with cardiovascular disease.
Keywords
drug-drug interactions; drug safety; adverse drug reactions; polypharmacy
Subject
Medicine and Pharmacology, Pharmacology and Toxicology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
