PreprintArticleVersion 1This version is not peer-reviewed
Amniotic Fluid and Maternal Serum Laeverin Levels and Their Correlations with Fetal Size and Placental Volume in the Second Trimester of Pregnancy—A Prospective Cross-Sectional Study
Version 1
: Received: 23 July 2024 / Approved: 23 July 2024 / Online: 24 July 2024 (02:52:01 CEST)
How to cite:
Sikovanyecz Jr., J.; Vincze, M.; Földesi, I.; Surányi, A.; Németh, G.; Sikovanyecz, J.; Kozinszky, Z. Amniotic Fluid and Maternal Serum Laeverin Levels and Their Correlations with Fetal Size and Placental Volume in the Second Trimester of Pregnancy—A Prospective Cross-Sectional Study. Preprints2024, 2024071793. https://doi.org/10.20944/preprints202407.1793.v1
Sikovanyecz Jr., J.; Vincze, M.; Földesi, I.; Surányi, A.; Németh, G.; Sikovanyecz, J.; Kozinszky, Z. Amniotic Fluid and Maternal Serum Laeverin Levels and Their Correlations with Fetal Size and Placental Volume in the Second Trimester of Pregnancy—A Prospective Cross-Sectional Study. Preprints 2024, 2024071793. https://doi.org/10.20944/preprints202407.1793.v1
Sikovanyecz Jr., J.; Vincze, M.; Földesi, I.; Surányi, A.; Németh, G.; Sikovanyecz, J.; Kozinszky, Z. Amniotic Fluid and Maternal Serum Laeverin Levels and Their Correlations with Fetal Size and Placental Volume in the Second Trimester of Pregnancy—A Prospective Cross-Sectional Study. Preprints2024, 2024071793. https://doi.org/10.20944/preprints202407.1793.v1
APA Style
Sikovanyecz Jr., J., Vincze, M., Földesi, I., Surányi, A., Németh, G., Sikovanyecz, J., & Kozinszky, Z. (2024). Amniotic Fluid and Maternal Serum Laeverin Levels and Their Correlations with Fetal Size and Placental Volume in the Second Trimester of Pregnancy—A Prospective Cross-Sectional Study. Preprints. https://doi.org/10.20944/preprints202407.1793.v1
Chicago/Turabian Style
Sikovanyecz Jr., J., János Sikovanyecz and Zoltan Kozinszky. 2024 "Amniotic Fluid and Maternal Serum Laeverin Levels and Their Correlations with Fetal Size and Placental Volume in the Second Trimester of Pregnancy—A Prospective Cross-Sectional Study" Preprints. https://doi.org/10.20944/preprints202407.1793.v1
Abstract
Introduction: Laeverin is an extravillous trophoblast marker playing a significant role in the trophoblast migration. The purpose of this study was to evaluate the association between the amniotic and serum laeverin concentrations at 16-22 weeks of gestation and the fetal and placental ultrasound measurements in healthy, unaffected pregnancies. Materials and methods: This was a prospective cross-sectional study. Pregnant women with singleton pregnancies undergoing amniocentesis were recruited consecutively. Fetal structural malformations and/or aneuploidy were exclusion criteria. Fetal biometric parameters and placental growth/perfusion were measured in 44 high-risk pregnancies who had no pregnancy complication and any other chronic disease. Maternal serum and amniotic levels of laeverin were essayed with sandwich enzyme-linked immunosorbent assay. Results: Serum laeverin levels are decreasing slightly with the maternal age in mid-gestation. Serum laeverin level correlated negatively slightly with head size of the fetus with the gestational length at delivery (β=-0.38, 95% confidence interval (CI) -0.03-0.01), while the amniotic laeverin level correlated strongly with the abdominal circumference of the fetus (β=-0.64, 95% CI: -0.03-0.01). Furthermore, laeverin level in the amnion correlated moderately and positively with the placental volume (β=0.46, 95% CI: 0.01-0.08). Conclusions: Laeverin levels detected in the serum and in the amniotic fluid denotes the fetoplacental growth in uncomplicated high-risk pregnancies.
Keywords
human laeverin; serum; amniotic fluid; fetus; placenta; ultrasound
Subject
Medicine and Pharmacology, Obstetrics and Gynaecology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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