Version 1
: Received: 23 July 2024 / Approved: 23 July 2024 / Online: 24 July 2024 (02:40:23 CEST)
How to cite:
Park, E. J.; Kim, L.; Lee, J.-O.; Lee, H.; Kim, Y. A.; Go, H. 6′-Sialyllactose Enhances Exercise Performance via Increased Muscle Mass and Strength. Preprints2024, 2024071823. https://doi.org/10.20944/preprints202407.1823.v1
Park, E. J.; Kim, L.; Lee, J.-O.; Lee, H.; Kim, Y. A.; Go, H. 6′-Sialyllactose Enhances Exercise Performance via Increased Muscle Mass and Strength. Preprints 2024, 2024071823. https://doi.org/10.20944/preprints202407.1823.v1
Park, E. J.; Kim, L.; Lee, J.-O.; Lee, H.; Kim, Y. A.; Go, H. 6′-Sialyllactose Enhances Exercise Performance via Increased Muscle Mass and Strength. Preprints2024, 2024071823. https://doi.org/10.20944/preprints202407.1823.v1
APA Style
Park, E. J., Kim, L., Lee, J. O., Lee, H., Kim, Y. A., & Go, H. (2024). 6′-Sialyllactose Enhances Exercise Performance via Increased Muscle Mass and Strength. Preprints. https://doi.org/10.20944/preprints202407.1823.v1
Chicago/Turabian Style
Park, E. J., Yong An Kim and Hiroe Go. 2024 "6′-Sialyllactose Enhances Exercise Performance via Increased Muscle Mass and Strength" Preprints. https://doi.org/10.20944/preprints202407.1823.v1
Abstract
Sialyllactose (SL) is a functional human milk oligosaccharide essential for immune support,
brain development, intestinal maturation, and antiviral defense. However, despite its
established health benefits, the effect of SL on exercise performance and muscle mass in mice
remains unknown. Here, we aimed to investigate, for the first time, the effects of 6′-SL on
muscle functions. Seven-week-old male C57BL/6J mice were administered 100 mg/kg 6′-SL
for 12 weeks, after which exhaustive treadmill performance, muscle strength, and muscle
phenotype were examined. The administration of 6′-SL significantly improved exhaustive
treadmill performance metrics, including distance and exhaustion time. Grip strength was also
increased by 6′-SL administration. Additionally, 6′-SL increased muscle mass in both the
gastrocnemius (GAS) and soleus. 6′-SL administration led to an increase in the minimum
Feret’s diameter and the protein expression of total myosin heavy chain in the GAS muscle. In
conclusion, 6′-SL administration in vivo led to increased running distance and time by
increasing muscle mass and strength. These findings collectively indicate that 6′-SL is a
potential agent for improving muscle health and exercise performance.
Keywords
6′-sialyllactose; exercise performance; muscle strength; muscle mass
Subject
Biology and Life Sciences, Biology and Biotechnology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
