Version 1
: Received: 22 July 2024 / Approved: 23 July 2024 / Online: 24 July 2024 (12:32:13 CEST)
How to cite:
Nyame, L.; Li, Y.; Fiagbey, E. D.; Xue, H.; Fan, L.; Du, W. Association of Vitamin A and Iron Supplementation on Major Clinical of Infectious Diseases in Ghanaian Children: A Cross-Sectional Study. Preprints2024, 2024071911. https://doi.org/10.20944/preprints202407.1911.v1
Nyame, L.; Li, Y.; Fiagbey, E. D.; Xue, H.; Fan, L.; Du, W. Association of Vitamin A and Iron Supplementation on Major Clinical of Infectious Diseases in Ghanaian Children: A Cross-Sectional Study. Preprints 2024, 2024071911. https://doi.org/10.20944/preprints202407.1911.v1
Nyame, L.; Li, Y.; Fiagbey, E. D.; Xue, H.; Fan, L.; Du, W. Association of Vitamin A and Iron Supplementation on Major Clinical of Infectious Diseases in Ghanaian Children: A Cross-Sectional Study. Preprints2024, 2024071911. https://doi.org/10.20944/preprints202407.1911.v1
APA Style
Nyame, L., Li, Y., Fiagbey, E. D., Xue, H., Fan, L., & Du, W. (2024). Association of Vitamin A and Iron Supplementation on Major Clinical of Infectious Diseases in Ghanaian Children: A Cross-Sectional Study. Preprints. https://doi.org/10.20944/preprints202407.1911.v1
Chicago/Turabian Style
Nyame, L., Lijun Fan and Wei Du. 2024 "Association of Vitamin A and Iron Supplementation on Major Clinical of Infectious Diseases in Ghanaian Children: A Cross-Sectional Study" Preprints. https://doi.org/10.20944/preprints202407.1911.v1
Abstract
Background: The utilization of nutrient supplementation as a tool to address issues such as iron and vitamin A deficiencies among children in Sub–Saharan Africa (SSA) has been beneficial. Nevertheless, there is a dearth of evidence on the effect of vitamin A and iron supplementation on infectious diseases in pre–school children in SSA. We aimed to assess the association of vitamin A and iron supplementation on the incidence of major clinical features of infectious diseases (diarrhea, cough, and fever) in children aged 6–59 months in Ghana. Methods: A cross–sectional study that utilized data from the Ghana Demographic and Health Survey, involving a sample size of 2,408 children. The collected data was analyzed using binomial logistic regression. Results: Dual supplementation with vitamin A and iron was associated with an increased risk of fever (OR: 1.68 95% CI: 1.22–2.32) and cough (OR: 1.43, 95% CI: 1.02–1.99) in children 6–59 months. Iron supplementation alone was associated with an increased risk of fever (OR: 1.32, 95% CI: 1.01–1.72) while Vitamin A alone significantly increased the risk of diarrhea (OR: 1.73, 95% CI: 1.03–2.92). Conclusions: Dual supplementation of vitamin A and iron is associated with an increase in childhood morbidity, endorsement of combined supplementation should be done with caution.
Keywords
iron; vitamin A; supplementation; infectious disease; preschool children
Subject
Medicine and Pharmacology, Medicine and Pharmacology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
