Version 1
: Received: 23 July 2024 / Approved: 24 July 2024 / Online: 24 July 2024 (13:05:39 CEST)
How to cite:
Gordon, S.; Roberti, A.; Kaufmann, S. H. E. Mononuclear Phagocytes, Cellular Immunity and Nobel Prizes: A Historic Perspective. Preprints2024, 2024071936. https://doi.org/10.20944/preprints202407.1936.v1
Gordon, S.; Roberti, A.; Kaufmann, S. H. E. Mononuclear Phagocytes, Cellular Immunity and Nobel Prizes: A Historic Perspective. Preprints 2024, 2024071936. https://doi.org/10.20944/preprints202407.1936.v1
Gordon, S.; Roberti, A.; Kaufmann, S. H. E. Mononuclear Phagocytes, Cellular Immunity and Nobel Prizes: A Historic Perspective. Preprints2024, 2024071936. https://doi.org/10.20944/preprints202407.1936.v1
APA Style
Gordon, S., Roberti, A., & Kaufmann, S. H. E. (2024). Mononuclear Phagocytes, Cellular Immunity and Nobel Prizes: A Historic Perspective. Preprints. https://doi.org/10.20944/preprints202407.1936.v1
Chicago/Turabian Style
Gordon, S., Annabell Roberti and Stefan Hugo Ernst Kaufmann. 2024 "Mononuclear Phagocytes, Cellular Immunity and Nobel Prizes: A Historic Perspective" Preprints. https://doi.org/10.20944/preprints202407.1936.v1
Abstract
The Mononuclear Phagocyte System includes monocytes, macrophages, some dendritic cells and multinuclear giant cells. These cell populations display marked heterogeneity depending on their differentiation from embryonic and bone marrow haematopoietic progenitors, tissue location and activation. They contribute to tissue homeostasis by interacting with local and systemic immune and non-immune cells, through trophic, clearance and cytocidal functions. During evolution they contributed to innate host defense before effector mechanisms of specific adaptive immunity emerged. Mouse macrophages appear at midgestation and are distributed throughout the embryo to facilitate organogenesis and clear cells undergoing programmed cell death. Yolk sac-, AGM- and foetal liver-derived tissue resident macrophages persist throughout postnatal and adult life, supplemented by bone marrow-derived blood monocytes, as required after injury and infection. Nobel awards to Elie Metchnikoff and Paul Ehrlich in 1908 drew attention to cellular phagocytic and humoral immunity, respectively. In 2011, prizes were awarded to Jules Hoffmann and Bruce Beutler for contributions to innate immunity and to Ralph Steinman for discovery of Dendritic Cells and their role in antigen presentation to T lymphocytes. We trace milestones in the history of mononuclear phagocyte research from the perspective of Nobel awards bearing directly and indirectly on their role in cellular immunity.
Keywords
Mononuclear Phagocyte System; Immunity; Macrophages; Dendritic Cells; Multinucleated Giant Cells; Nobel Prizes; Phagocytosis; Plasma Membrane Receptors; Homeostasis; History
Subject
Biology and Life Sciences, Immunology and Microbiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
