PreprintArticleVersion 1This version is not peer-reviewed
Real-World Evidence of the Effectiveness and Safety of Ciclopirox 8% HPCH Nail Lacquer Combined with Oral Antifungals for Onychomycosis Applying Artificial Intelligence to Electronic Health Records
Version 1
: Received: 24 July 2024 / Approved: 24 July 2024 / Online: 25 July 2024 (03:20:04 CEST)
How to cite:
Roustan, G.; López Estébaranz, J. L.; De La Cueva, P.; Research Group, S.; Pajuelo, F.; Tamarit, M. L.; Valmaseda, A.; Galván, J. Real-World Evidence of the Effectiveness and Safety of Ciclopirox 8% HPCH Nail Lacquer Combined with Oral Antifungals for Onychomycosis Applying Artificial Intelligence to Electronic Health Records. Preprints2024, 2024071944. https://doi.org/10.20944/preprints202407.1944.v1
Roustan, G.; López Estébaranz, J. L.; De La Cueva, P.; Research Group, S.; Pajuelo, F.; Tamarit, M. L.; Valmaseda, A.; Galván, J. Real-World Evidence of the Effectiveness and Safety of Ciclopirox 8% HPCH Nail Lacquer Combined with Oral Antifungals for Onychomycosis Applying Artificial Intelligence to Electronic Health Records. Preprints 2024, 2024071944. https://doi.org/10.20944/preprints202407.1944.v1
Roustan, G.; López Estébaranz, J. L.; De La Cueva, P.; Research Group, S.; Pajuelo, F.; Tamarit, M. L.; Valmaseda, A.; Galván, J. Real-World Evidence of the Effectiveness and Safety of Ciclopirox 8% HPCH Nail Lacquer Combined with Oral Antifungals for Onychomycosis Applying Artificial Intelligence to Electronic Health Records. Preprints2024, 2024071944. https://doi.org/10.20944/preprints202407.1944.v1
APA Style
Roustan, G., López Estébaranz, J. L., De La Cueva, P., Research Group, S., Pajuelo, F., Tamarit, M. L., Valmaseda, A., & Galván, J. (2024). Real-World Evidence of the Effectiveness and Safety of Ciclopirox 8% HPCH Nail Lacquer Combined with Oral Antifungals for Onychomycosis Applying Artificial Intelligence to Electronic Health Records. Preprints. https://doi.org/10.20944/preprints202407.1944.v1
Chicago/Turabian Style
Roustan, G., Aida Valmaseda and Jordi Galván. 2024 "Real-World Evidence of the Effectiveness and Safety of Ciclopirox 8% HPCH Nail Lacquer Combined with Oral Antifungals for Onychomycosis Applying Artificial Intelligence to Electronic Health Records" Preprints. https://doi.org/10.20944/preprints202407.1944.v1
Abstract
A multicenter retrospective analysis of 408 patients diagnosed with onychomycosis and attended at three tertiary care Spanish hospitals was conducted to assess the effectiveness and safety of a combined treatment with ciclopirox 8% hydroxypropyl chitosan (CPX 8% HPCH) nail lacquer and oral antifungal agents (terbinafine, itraconazole, and fluconazole). Data were extracted and analyzed using the EHRead® technology based on natural language processing and machine learning and using SNOMED CT terminology. The median age was 51 years with a ratio male: female close to 1. Repeated nail trauma was the most common risk factor (7.1%). More than half of patients (56.6%) underwent fungal culture. Terbinafine was used in 67.7% of patients, itraconazole in 20.8%, and fluconazole in 11.5%. Treatment synchronicity distribution revealed that 59.1% of patients started concomitant treatment with CPX 8% HPCH and oral antifungals, 27.9% had initial oral antifungals, and 13% had initial nail lacquer. The response to treatment (positive response 15.7%, presumed positive 59.8%) was unrelated to treatment synchronicity or type of antifungal agent. Erythema (5.6%), diarrhea (4.9%) and fever (4.2%) were the most frequently registered potential adverse events. The present findings provide valuable insights for physicians paving the way for better management of patients with onychomycosis.
Medicine and Pharmacology, Pharmacology and Toxicology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
