Modulation of Integrin αvβ3 Activation and Signaling in BV-2 Microglial Cells and THP-1 Monocytes by Thyroid Hormones

How to cite: Gionfra, F.; D'Ezio, V.; De Luca, R.; Candelotti, E.; Leone, S.; Percario, Z.; Persichini, T.; Colasanti, M.; Affabris, E.; Lin, H. .-Y.; Davis, P. J.; Pedersen, J. Z.; Incerpi, S. Modulation of Integrin αvβ3 Activation and Signaling in BV-2 Microglial Cells and THP-1 Monocytes by Thyroid Hormones. Preprints 2024, 2024071956. https://doi.org/10.20944/preprints202407.1956.v1 Gionfra, F.; D'Ezio, V.; De Luca, R.; Candelotti, E.; Leone, S.; Percario, Z.; Persichini, T.; Colasanti, M.; Affabris, E.; Lin, H. .-Y.; Davis, P. J.; Pedersen, J. Z.; Incerpi, S. Modulation of Integrin αvβ3 Activation and Signaling in BV-2 Microglial Cells and THP-1 Monocytes by Thyroid Hormones. Preprints 2024, 2024071956. https://doi.org/10.20944/preprints202407.1956.v1

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MDPI and ACS Style

Gionfra, F.; D'Ezio, V.; De Luca, R.; Candelotti, E.; Leone, S.; Percario, Z.; Persichini, T.; Colasanti, M.; Affabris, E.; Lin, H. .-Y.; Davis, P. J.; Pedersen, J. Z.; Incerpi, S. Modulation of Integrin αvβ3 Activation and Signaling in BV-2 Microglial Cells and THP-1 Monocytes by Thyroid Hormones. Preprints 2024, 2024071956. https://doi.org/10.20944/preprints202407.1956.v1

APA Style

Gionfra, F., D'Ezio, V., De Luca, R., Candelotti, E., Leone, S., Percario, Z., Persichini, T., Colasanti, M., Affabris, E., Lin, H. . Y., Davis, P. J., Pedersen, J. Z., & Incerpi, S. (2024). Modulation of Integrin αvβ3 Activation and Signaling in BV-2 Microglial Cells and THP-1 Monocytes by Thyroid Hormones. Preprints. https://doi.org/10.20944/preprints202407.1956.v1

Chicago/Turabian Style

Gionfra, F., Jens Z. Pedersen and Sandra Incerpi. 2024 "Modulation of Integrin αvβ3 Activation and Signaling in BV-2 Microglial Cells and THP-1 Monocytes by Thyroid Hormones" Preprints. https://doi.org/10.20944/preprints202407.1956.v1

Abstract

Much evidence now indicates a direct crosstalk between thyroid hormones (THs) and the immune system. We previously showed that THs behave as anti-inflammatory agents in human leukemic THP-1 monocytes, but a potential neuroprotective effect of THs in microglia have been under-investigated. Microglia, the primary innate immune cells of the brain, play a pivotal role in the regulation of neuroinflammation and nongenomic integrin αvβ3-mediated action of THs appear to be involved. Integrin αvβ3 was highly expressed in activated BV-2 cells, while it was decreased by THs. In addition, THs facilitated wound healing in BV-2 murine microglia cells activated by lipopolysaccharide (LPS), through integrin αvβ3 and reactive oxygen species (ROS), with tetrac (a metabolite of TH) potentiated the inhibition of migration. Nitric oxide (NO) played a role with different mechanisms in the presence of either T3 or T4. Our data showed the capability of TH and analogues to modulate the M1-to-M2 microglial transition and suggest a new spectrum of actions in the central nervous system (CNS).

Keywords

microglia; thyroid hormone; tetraiodothyroacetic acid (tetrac); integrin αvβ3; lipopolysaccharide (LPS); wound healing; migration; reactive oxygen species (ROS); nitric oxide (NO); neuroinflammation

Subject

Biology and Life Sciences, Immunology and Microbiology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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