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2024 Update on Position Statement by Experts from the Polish Society of Allergology and the Polish Respiratory Society on the Evaluation of Efficacy and Effectiveness of Single Inhaler Triple Therapies in Asthma Treatment
Version 1
: Received: 24 July 2024 / Approved: 25 July 2024 / Online: 26 July 2024 (11:32:02 CEST)
How to cite:
Śliwiński, P.; Antczak, A.; Barczyk, A.; Białas, A. J.; Czajkowska-Malinowska, M.; Jahnz-Różyk, K.; Kulus, M.; Kuna, P.; Kupczyk, M. 2024 Update on Position Statement by Experts from the Polish Society of Allergology and the Polish Respiratory Society on the Evaluation of Efficacy and Effectiveness of Single Inhaler Triple Therapies in Asthma Treatment. Preprints2024, 2024072049. https://doi.org/10.20944/preprints202407.2049.v1
Śliwiński, P.; Antczak, A.; Barczyk, A.; Białas, A. J.; Czajkowska-Malinowska, M.; Jahnz-Różyk, K.; Kulus, M.; Kuna, P.; Kupczyk, M. 2024 Update on Position Statement by Experts from the Polish Society of Allergology and the Polish Respiratory Society on the Evaluation of Efficacy and Effectiveness of Single Inhaler Triple Therapies in Asthma Treatment. Preprints 2024, 2024072049. https://doi.org/10.20944/preprints202407.2049.v1
Śliwiński, P.; Antczak, A.; Barczyk, A.; Białas, A. J.; Czajkowska-Malinowska, M.; Jahnz-Różyk, K.; Kulus, M.; Kuna, P.; Kupczyk, M. 2024 Update on Position Statement by Experts from the Polish Society of Allergology and the Polish Respiratory Society on the Evaluation of Efficacy and Effectiveness of Single Inhaler Triple Therapies in Asthma Treatment. Preprints2024, 2024072049. https://doi.org/10.20944/preprints202407.2049.v1
APA Style
Śliwiński, P., Antczak, A., Barczyk, A., Białas, A. J., Czajkowska-Malinowska, M., Jahnz-Różyk, K., Kulus, M., Kuna, P., & Kupczyk, M. (2024). 2024 Update on Position Statement by Experts from the Polish Society of Allergology and the Polish Respiratory Society on the Evaluation of Efficacy and Effectiveness of Single Inhaler Triple Therapies in Asthma Treatment. Preprints. https://doi.org/10.20944/preprints202407.2049.v1
Chicago/Turabian Style
Śliwiński, P., Piotr Kuna and Maciej Kupczyk. 2024 "2024 Update on Position Statement by Experts from the Polish Society of Allergology and the Polish Respiratory Society on the Evaluation of Efficacy and Effectiveness of Single Inhaler Triple Therapies in Asthma Treatment" Preprints. https://doi.org/10.20944/preprints202407.2049.v1
Abstract
Medication non-adherence remains a substantial obstacle in asthma care, prompting the exploration of novel therapeutic modalities that prioritize rapid symptom relief, anti-inflammatory activity and facilitate patients’ compliance. This task is well served by a new form of therapy - inhaled triple-combination medications ICS/LABA/LAMA (inhaled glucocorticosteroid/long-acting beta2-agonist/long-acting muscarinic antagonist). The integration of three medications within a singular inhalation device culminates in the reduction of the effective dose of the principal therapeutic agent for asthma management, namely, ICS. This consolidation yields a dual benefit of minimizing the likelihood of adverse effects typically linked with ICS while concurrently optimizing bronchodilator efficacy. The accumulated evidence suggests that adding LAMA to a medium- or high-dose ICS/LABA results in a decrease of asthma exacerbations compared to medium- or high-dose ICS/LABA alone, accompanied by sustained enhancements in lung function parameters. We propose in adult patients experiencing suboptimal asthma control despite medium/high-dose ICS/LABA treatment - regardless of adherence to GINA-recommended strategies, such as MART therapy as a first-line approach or alternative second-line strategies - the preferred course for intensifying asthma therapy involves the addition of a LAMA, ideally in the form of SITT.
Keywords
asthma; asthma treatment; ICS/LABA; LAMA; single inhaler triple therapy; SITT
Subject
Medicine and Pharmacology, Pulmonary and Respiratory Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
