Peris-Fernández, M.; Roca-Marugán, M. I.; Amengual, J. L.; Balaguer, A.; Viejo-Boyano, I.; Soldevila-Orient, A.; Devesa-Such, R.; Sánchez-Pérez, P.; Hernández-Jaras, J. Uremic Toxins and Inflammation: Metabolic Pathways Affected in Patients Undergoing Renal Replacement Therapies. Preprints2024, 2024072068. https://doi.org/10.20944/preprints202407.2068.v1
APA Style
Peris-Fernández, M., Roca-Marugán, M. I., Amengual, J. L., Balaguer, A., Viejo-Boyano, I., Soldevila-Orient, A., Devesa-Such, R., Sánchez-Pérez, P., & Hernández-Jaras, J. (2024). Uremic Toxins and Inflammation: Metabolic Pathways Affected in Patients Undergoing Renal Replacement Therapies. Preprints. https://doi.org/10.20944/preprints202407.2068.v1
Chicago/Turabian Style
Peris-Fernández, M., Pilar Sánchez-Pérez and Julio Hernández-Jaras. 2024 "Uremic Toxins and Inflammation: Metabolic Pathways Affected in Patients Undergoing Renal Replacement Therapies" Preprints. https://doi.org/10.20944/preprints202407.2068.v1
Abstract
3.9 million individuals rely on kidney replacement therapy worldwide. They experience height-ened susceptibility to cardiovascular diseases and mortality, alongside an increased risk of in-fections and malignancies, with inflammation being key to explaining this intensified risk. This study utilized semi-targeted metabolomics to explore novel metabolic pathways related to in-flammation in this populations. We collected pre and post-session blood samples of patients who had already undergone one year of chronic hemodialysis. And used liquid chromatography and high resolution mass spectrometry to perform a metabolomic analysis. Afterwards, we employed both univariate (Mann-Whitney test) and multivariate (logistic regression with LASSO regulari-zation) to identify metabolites associated with inflammation. In the univariate analysis, in-dole-3-acetaldehyde, 2-ketobutyric acid, and urocanic acid showed statistically significant de-creases in median concentrations in the presence of inflammation. In the multivariate analysis, metabolites positively associated with inflammation include allantoin, taurodeoxycholic acid, norepinephrine, pyroglutamic acid, and L-hydroorotic acid. Conversely, metabolites showing negative associations with inflammation include benzoic acid, indole-3-acetaldehyde, methio-nine, citrulline, alphaketoglutarate, n-acetyl-ornithine and 3-4-dihydroxibenzeneacetic acid. Non inflamed patients exhibit preserved autophagy and reduced mitochondrial dysfunction. Under-standing inflammation in this group hinges on the metabolism of arginine and the urea cycle. Additionally, the microbiota, particularly uricase-producing bacteria and those metabolizing tryptophan, play critical roles.
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
