Review
Version 1
This version is not peer-reviewed
Advances in Dendritic Cell-Based Vaccines Against Respiratory Fungal Infections
Version 1
: Received: 24 July 2024 / Approved: 25 July 2024 / Online: 26 July 2024 (06:02:19 CEST)
How to cite: Kulkarni, N. A.; Nanjappa, S. G. Advances in Dendritic Cell-Based Vaccines Against Respiratory Fungal Infections. Preprints 2024, 2024072092. https://doi.org/10.20944/preprints202407.2092.v1 Kulkarni, N. A.; Nanjappa, S. G. Advances in Dendritic Cell-Based Vaccines Against Respiratory Fungal Infections. Preprints 2024, 2024072092. https://doi.org/10.20944/preprints202407.2092.v1
Abstract
Ever since the discovery of dendritic cells by Ralph Steinman and Zanvil Cohn in 1973, it is increasingly evident that dendritic cells are integral for adaptive immune responses, and there is an undeniable focus on them for vaccines development. Fungal infections, often thought in-nocuous, are becoming significant threats due to increased immunocompromised or im-mune-suppressed population and climate change. Further, the recent COVID-19 pandemic unraveled the wrath of fungal infections and devastating outcomes. Invasive fungal infections cause significant case fatality rates ranging from 20% to 90%. Regrettably, no licensed fungal vaccines exist, and there is an urgent need for preventive and therapeutic purposes. In this re-view, we discuss the ontogeny, subsets, tissue distribution, and functions of lung dendritic cells. In the latter part, we summarize and discuss the studies on the DC-based vaccines against pulmonary fungal infections. Finally, we highlight some emerging potential avenues that can be incorporated for DC-based vaccines against fungal infections.
Keywords
dendritic cells; pulmonary fungal infections; DC-based vaccine; adaptive immune response
Subject
Medicine and Pharmacology, Immunology and Allergy
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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