Low-Dose Oral Misoprostol Versus Oxytocin Infusion For Induction Of Labor In Pregnant Women With Term Premature Rupture Of Membranes in China: A Prospective Nested Case-Control Study

Yike Yang; Zhiheng Yu; Huifeng Shi; Yan Wang; Yangyu Zhao

doi:10.20944/preprints202407.2106.v1

Preprint Article Version 1 This version is not peer-reviewed

Version 1 : Received: 25 July 2024 / Approved: 25 July 2024 / Online: 26 July 2024 (06:17:37 CEST)

Background: Oxytocin is recommended as the first-line choice for labor induction in term pregnant women with premature rupture of membranes (PROM); however, it can occasionally lead to failed induction and delivery complications. The primary objective of this study was to compare delivery information and outcomes following the administration of oxytocin infusion or oral low-dose misoprostol solution for labor induction in term PROM women with an unfavorable cervical condition. Methods: A prospective nested case-control study was conducted at a tertiary general hospital in China from March 2020 to February 2024, comparing oxytocin infusion and oral administration of 25ug misoprostol every 2 hours for labor induction in term PROM women with a Bishop score

Premature rupture of membrane; Oxytocin infusion; Oral low-dose misoprostol; Vaginal delivery; Failed induction of labor; Postpartum hemorrhage

Medicine and Pharmacology, Obstetrics and Gynaecology

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Low-Dose Oral Misoprostol Versus Oxytocin Infusion For Induction Of Labor In Pregnant Women With Term Premature Rupture Of Membranes in China: A Prospective Nested Case-Control Study

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