Version 1
: Received: 25 July 2024 / Approved: 26 July 2024 / Online: 26 July 2024 (12:54:17 CEST)
How to cite:
Khimani, F.; Haase, E.; Kulkarni, C.; Moore, P.; Murdock, P.; Ramanathan, A. V.; Wolf, A.; Sathyamoorthy, M. The Association of High Burden Premature Ventricular Contractions With Esophageal/Upper GI Diseases. Preprints2024, 2024072143. https://doi.org/10.20944/preprints202407.2143.v1
Khimani, F.; Haase, E.; Kulkarni, C.; Moore, P.; Murdock, P.; Ramanathan, A. V.; Wolf, A.; Sathyamoorthy, M. The Association of High Burden Premature Ventricular Contractions With Esophageal/Upper GI Diseases. Preprints 2024, 2024072143. https://doi.org/10.20944/preprints202407.2143.v1
Khimani, F.; Haase, E.; Kulkarni, C.; Moore, P.; Murdock, P.; Ramanathan, A. V.; Wolf, A.; Sathyamoorthy, M. The Association of High Burden Premature Ventricular Contractions With Esophageal/Upper GI Diseases. Preprints2024, 2024072143. https://doi.org/10.20944/preprints202407.2143.v1
APA Style
Khimani, F., Haase, E., Kulkarni, C., Moore, P., Murdock, P., Ramanathan, A. V., Wolf, A., & Sathyamoorthy, M. (2024). The Association of High Burden Premature Ventricular Contractions With Esophageal/Upper GI Diseases. Preprints. https://doi.org/10.20944/preprints202407.2143.v1
Chicago/Turabian Style
Khimani, F., Adam Wolf and Mohanakrishnan Sathyamoorthy. 2024 "The Association of High Burden Premature Ventricular Contractions With Esophageal/Upper GI Diseases" Preprints. https://doi.org/10.20944/preprints202407.2143.v1
Abstract
Seven patients in our clinical program who were diagnosed with high burden (>10%) premature ventricular contractions (PVCs) and concomitant significant upper GI disease with no other significant cardiac history demonstrated a significant reduction in the burden of PVCs following surgical or procedural interventions of the upper GI tract [68.34% reduction, p=0.024). Furthermore, in all cases, the origin of the PVCs was from the base of the right ventricular outflow tract (RVOT). This is the first report in the literature that we are aware of to report this unique association for which we propose a dual mechanism of action of vagally mediated upper GI driven PVCs and a direct anatomical effect of these upper GI anatomies on the right ventricular outflow tract (RVOT) of the heart. These are very prelimary findings that warrant larger clinical and mechanistic studies that may ultimately define a new subset of PVCs for which we propose a term, “E-PVCs”.
Medicine and Pharmacology, Cardiac and Cardiovascular Systems
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
