Version 1
: Received: 26 July 2024 / Approved: 27 July 2024 / Online: 30 July 2024 (08:57:05 CEST)
How to cite:
Matsuda, K.; Kariya, R.; Maeda, K.; Okada, S. Potent Anti-HIV-1 Activity of Sacran, a Megamolecular Polysaccharide from Cyanobacterium Aphanothece sacrum, as a Microbicide Candidate. Preprints2024, 2024072237. https://doi.org/10.20944/preprints202407.2237.v1
Matsuda, K.; Kariya, R.; Maeda, K.; Okada, S. Potent Anti-HIV-1 Activity of Sacran, a Megamolecular Polysaccharide from Cyanobacterium Aphanothece sacrum, as a Microbicide Candidate. Preprints 2024, 2024072237. https://doi.org/10.20944/preprints202407.2237.v1
Matsuda, K.; Kariya, R.; Maeda, K.; Okada, S. Potent Anti-HIV-1 Activity of Sacran, a Megamolecular Polysaccharide from Cyanobacterium Aphanothece sacrum, as a Microbicide Candidate. Preprints2024, 2024072237. https://doi.org/10.20944/preprints202407.2237.v1
APA Style
Matsuda, K., Kariya, R., Maeda, K., & Okada, S. (2024). Potent Anti-HIV-1 Activity of Sacran, a Megamolecular Polysaccharide from Cyanobacterium <em>Aphanothece sacrum</em>, as a Microbicide Candidate. Preprints. https://doi.org/10.20944/preprints202407.2237.v1
Chicago/Turabian Style
Matsuda, K., Kenji Maeda and Seiji Okada. 2024 "Potent Anti-HIV-1 Activity of Sacran, a Megamolecular Polysaccharide from Cyanobacterium <em>Aphanothece sacrum</em>, as a Microbicide Candidate" Preprints. https://doi.org/10.20944/preprints202407.2237.v1
Abstract
Since cART was introduced to treat AIDS, the mortality rate due to AIDS has markedly decreased and the convalescence of HIV-infected individuals has improved drastically. However, HIV-1 sexual transmission has made HIV become a global epidemic. Sacran is a megamolecular poly-saccharide extracted from cyanobacterium Aphanothece sacrum that exhibits numerous desirable characteristics for transdermic applications, such as safety as a biomaterial, a high moisture re-tention effect, the ability to form a film and hydrogel, and an anti-inflammatory effect. In this study, we evaluated the anti-HIV-1 effects of Sacran as a barrier to HIV transmission. Sacran inhibited HIV-1 infection and envelope-dependent cell-to-cell fusion. Moreover, we used a Transwell assay to confirm that sacran inhibited viral diffusion and captured viruses. The synergistic effects of sacran and other anti-HIV infection drugs were also evaluated.HIV-1 infections can be reduced through the synergistic effects of sacran and anti-HIV-1 drugs. Our study suggests the use of sacran gel to protect against HIV-1 transmission.
Keywords
sacran; HIV-1; microbicide
Subject
Medicine and Pharmacology, Epidemiology and Infectious Diseases
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
