Preprint Review Version 1 This version is not peer-reviewed

Non-Obstructive Coronary Artery Disease and Atrial Fibrillation: A Complex Interplay with One Begets Another

Alexandru-Florinel Oancea
,
Paula Cristina Morariu
* ,
Ana Maria Buburuz
* ,
Ionela-Larisa Miftode
,
Radu Stefan Miftode
,
Ovidiu Mitu
,
Alexandru Jigoranu
,
Diana-Elena Floria
,
Amalia Timpau
,
Andrei Vata
,
Claudia Plesca
,
Gina Botnariu
,
Alexandru Burlacu
,
Dragos -Viorel Scripcariu
,
Mitea Raluca
,
Magdalena Cuciureanu
,
Daniela Maria Tanase
,
Irina Iuliana Costache-Enache
,
Mariana Floria
Version 1 : Received: 28 July 2024 / Approved: 28 July 2024 / Online: 30 July 2024 (10:00:57 CEST)

How to cite: Oancea, A.-F.; Morariu, P. C.; Buburuz, A. M.; Miftode, I.-L.; Miftode, R. S.; Mitu, O.; Jigoranu, A.; Floria, D.-E.; Timpau, A.; Vata, A.; Plesca, C.; Botnariu, G.; Burlacu, A.; Scripcariu, D. .-V.; Raluca, M.; Cuciureanu, M.; Tanase, D. M.; Costache-Enache, I. I.; Floria, M. Non-Obstructive Coronary Artery Disease and Atrial Fibrillation: A Complex Interplay with One Begets Another. Preprints 2024, 2024072243. https://doi.org/10.20944/preprints202407.2243.v1 Oancea, A.-F.; Morariu, P. C.; Buburuz, A. M.; Miftode, I.-L.; Miftode, R. S.; Mitu, O.; Jigoranu, A.; Floria, D.-E.; Timpau, A.; Vata, A.; Plesca, C.; Botnariu, G.; Burlacu, A.; Scripcariu, D. .-V.; Raluca, M.; Cuciureanu, M.; Tanase, D. M.; Costache-Enache, I. I.; Floria, M. Non-Obstructive Coronary Artery Disease and Atrial Fibrillation: A Complex Interplay with One Begets Another. Preprints 2024, 2024072243. https://doi.org/10.20944/preprints202407.2243.v1

Abstract

This article aims to analyze the relationship between non-obstructive coronary artery disease (NOCAD) and atrial fibrillation (AF), exploring the underlying pathophysiological mechanisms and implications for clinical management. NOCAD and AF are prevalent cardiovascular conditions that often coexist, yet their interrelation is not well understood. NOCAD, characterized by the presence of atherosclerotic plaques without significant luminal stenosis, can lead to ischemic necrosis of cardiomyocytes and their replacement with fibrous tissue, in this way sustaining the focal ectopic activity in atrial myocardium. Atrial fibrillation, on the other hand, is the most common sustained cardiac arrhythmia, associated with an increased risk of stroke and heart failure, which may accelerate atherosclerosis and may increase oxygen consumption in the myocardium, creating a mismatch between supply and demand, thus promoting the development or worsening of coronary ischemia. Therefore, NOCAD and AF seems to be a complex Interplay with one begets another.

Keywords

coronary ischemia; non-obstructive coronary artery disease; INOCA; MINOCA; ANOCA; atrial fibrillation

Subject

Medicine and Pharmacology, Cardiac and Cardiovascular Systems

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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