Version 1
: Received: 26 July 2024 / Approved: 29 July 2024 / Online: 29 July 2024 (08:55:53 CEST)
How to cite:
Minelli, M.; Anaclerio, F.; Calisi, D.; Onofrj, M.; Antonucci, I.; Gatta, V.; Stuppia, L. Application of Metagenomics Sequencing in a Patient with Dementia: A New Case Report. Preprints2024, 2024072269. https://doi.org/10.20944/preprints202407.2269.v1
Minelli, M.; Anaclerio, F.; Calisi, D.; Onofrj, M.; Antonucci, I.; Gatta, V.; Stuppia, L. Application of Metagenomics Sequencing in a Patient with Dementia: A New Case Report. Preprints 2024, 2024072269. https://doi.org/10.20944/preprints202407.2269.v1
Minelli, M.; Anaclerio, F.; Calisi, D.; Onofrj, M.; Antonucci, I.; Gatta, V.; Stuppia, L. Application of Metagenomics Sequencing in a Patient with Dementia: A New Case Report. Preprints2024, 2024072269. https://doi.org/10.20944/preprints202407.2269.v1
APA Style
Minelli, M., Anaclerio, F., Calisi, D., Onofrj, M., Antonucci, I., Gatta, V., & Stuppia, L. (2024). Application of Metagenomics Sequencing in a Patient with Dementia: A New Case Report. Preprints. https://doi.org/10.20944/preprints202407.2269.v1
Chicago/Turabian Style
Minelli, M., Valentina Gatta and Liborio Stuppia. 2024 "Application of Metagenomics Sequencing in a Patient with Dementia: A New Case Report" Preprints. https://doi.org/10.20944/preprints202407.2269.v1
Abstract
(1) Background: The study of microbiome is being crucial for his role in major systemic diseases, in particular the oral and gut microbiota. In the last years the study of microorganism correlated for example with neurodegenerative disease is increasing the prospective of a possible link between gut microbiota and brain. Here we report a new case report about a patient evaluated genetically firstly for dementia and late-onset dyskinesia, and then tested with 16S metagenomics sequencing. (2) Methods: Starting from buccal swab, we extracted bacterial DNA and then we performed a NGS metagenomics sequencing based on the amplification of hypervariable regions of the 16S in bacteria. (3) Results: The sequencing revealed the presence of Spirochaetes Phylum, a pathogenic bacterium generally known to be able to migrate to the Central Nervous System and not only. (4) Conclusions: Oral infections as our results shows could be possible contributing factors to various neurodegenerative conditions.
Public Health and Healthcare, Public Health and Health Services
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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