Version 1
: Received: 30 May 2024 / Approved: 31 May 2024 / Online: 31 May 2024 (08:10:58 CEST)
How to cite:
Reiriz, M.; Beltrán-Velasco, A. I.; Echeverry-Alzate, V.; Martínez-Miguel, E.; Gómez-Senent, S.; Uceda, S.; Clemente-Suárez, V. J. Bifidobacterium infantis and Bifidobacterium breve Improve Symptomatology and Neuronal Damage in Neurodegenerative Disease. A Systematic Review.. Preprints2024, 2024052103. https://doi.org/10.20944/preprints202405.2103.v1
Reiriz, M.; Beltrán-Velasco, A. I.; Echeverry-Alzate, V.; Martínez-Miguel, E.; Gómez-Senent, S.; Uceda, S.; Clemente-Suárez, V. J. Bifidobacterium infantis and Bifidobacterium breve Improve Symptomatology and Neuronal Damage in Neurodegenerative Disease. A Systematic Review.. Preprints 2024, 2024052103. https://doi.org/10.20944/preprints202405.2103.v1
Reiriz, M.; Beltrán-Velasco, A. I.; Echeverry-Alzate, V.; Martínez-Miguel, E.; Gómez-Senent, S.; Uceda, S.; Clemente-Suárez, V. J. Bifidobacterium infantis and Bifidobacterium breve Improve Symptomatology and Neuronal Damage in Neurodegenerative Disease. A Systematic Review.. Preprints2024, 2024052103. https://doi.org/10.20944/preprints202405.2103.v1
APA Style
Reiriz, M., Beltrán-Velasco, A. I., Echeverry-Alzate, V., Martínez-Miguel, E., Gómez-Senent, S., Uceda, S., & Clemente-Suárez, V. J. (2024). <em>Bifidobacterium infantis</em> and Bifidobacterium breve Improve Symptomatology and Neuronal Damage in Neurodegenerative Disease. A Systematic Review.. Preprints. https://doi.org/10.20944/preprints202405.2103.v1
Chicago/Turabian Style
Reiriz, M., Sara Uceda and Vicente Javier Clemente-Suárez. 2024 "<em>Bifidobacterium infantis</em> and Bifidobacterium breve Improve Symptomatology and Neuronal Damage in Neurodegenerative Disease. A Systematic Review." Preprints. https://doi.org/10.20944/preprints202405.2103.v1
Abstract
: This Systematic Review focused on the use of Bifidobacterium infantis and Bifidobacterium breve in neurodegenerative diseases. The study of metabolomics has demonstrated the relationship between dysbiosis and neuronal death. The modulation of the gut microbiota in the intervention of these pathologies has become a promising area of study, showing beneficial results such as the improvement of synaptic function, the reduction of neuroinflammation, as well as the improvement of associated neuropsychiatric symptoms. Several studies have addressed the administration of Bifidobacterium infantis and Bifidobacterium breve, alone, in conjunction or in combination with other strains, in the intervention of neurodegenerative diseases. This Systematic Review includes the results of 17 research articles (n=5 in humans and n=12 in animal models) and the main result was that the use of these Bifidobacterium strains, alone, in conjunction or in combination with other strains, produced improvements in neurodegenerative disease-related symptomatology and degenerative cellular processes. However, some studies shown neutral results in certain variables. These data suggest that the use of these probiotics has a neuroprotective effect that may delay the progression of the disease. This research provides relevant and updated information on the use of these Bifidobacterium strains in neurodegenerative pathologies such as Alzheimer's disease and Parkinson's disease.
Biology and Life Sciences, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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