Mechanisms of Gut-Related Viral Persistence in Long Covid

Philip McMillan; Anthony J. Turner; Bruce D. Uhal

doi:10.20944/preprints202407.2270.v1

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preprints.org > biology and life sciences > virology > doi: 10.20944/preprints202407.2270.v1 (registering DOI)

Preprint Review Version 1 This version is not peer-reviewed

Mechanisms of Gut-Related Viral Persistence in Long Covid

Philip McMillan

Anthony J. Turner

Bruce D. Uhal

Version 1 : Received: 26 July 2024 / Approved: 29 July 2024 / Online: 29 July 2024 (08:32:10 CEST)

How to cite: McMillan, P.; Turner, A. J.; Uhal, B. D. Mechanisms of Gut-Related Viral Persistence in Long Covid. Preprints 2024, 2024072270. https://doi.org/10.20944/preprints202407.2270.v1 McMillan, P.; Turner, A. J.; Uhal, B. D. Mechanisms of Gut-Related Viral Persistence in Long Covid. Preprints 2024, 2024072270. https://doi.org/10.20944/preprints202407.2270.v1

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MDPI and ACS Style

McMillan, P.; Turner, A. J.; Uhal, B. D. Mechanisms of Gut-Related Viral Persistence in Long Covid. Preprints 2024, 2024072270. https://doi.org/10.20944/preprints202407.2270.v1

APA Style

McMillan, P., Turner, A. J., & Uhal, B. D. (2024). Mechanisms of Gut-Related Viral Persistence in Long Covid. Preprints. https://doi.org/10.20944/preprints202407.2270.v1

Chicago/Turabian Style

McMillan, P., Anthony J. Turner and Bruce D. Uhal. 2024 "Mechanisms of Gut-Related Viral Persistence in Long Covid" Preprints. https://doi.org/10.20944/preprints202407.2270.v1

Abstract

Long COVID (Post-Acute Sequelae of COVID-19, PASC) is a consequence of infection by SARS-CoV-2 that continues to disrupt the well-being of millions of affected individuals for many months beyond their first infection. While the exact mechanisms underlying PASC remain to be defined, hypotheses regarding the pathogenesis of Long COVID are varied and include (but are not limited to) dysregulated local or systemic inflammatory responses, autoimmune mechanisms, viral-induced hormonal imbalances and long-term persistence of virus and/or fragments of viral RNA or proteins. This review article is based on a comprehensive review of the wide range of symptoms most often observed in long COVID and an attempt to integrate that information into a plausible hypothesis for the pathogenesis of PASC. In particular, it is proposed that longterm dysregulation of the gut in response to viral persistence could lead to the myriad of symptoms observed in PASC.

Keywords

Long COVID; PASC; viral persistence; gut; SARS-CoV-2

Subject

Biology and Life Sciences, Virology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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