Version 1
: Received: 29 July 2024 / Approved: 29 July 2024 / Online: 29 July 2024 (14:03:28 CEST)
How to cite:
Dąbrowska, A.; Wilczyński, B.; Mastalerz, J.; Kulbacka, J.; Szewczyk, A.; Rembiałkowska, N. The Impact of Liver Failure on the Immune System. Preprints2024, 2024072321. https://doi.org/10.20944/preprints202407.2321.v1
Dąbrowska, A.; Wilczyński, B.; Mastalerz, J.; Kulbacka, J.; Szewczyk, A.; Rembiałkowska, N. The Impact of Liver Failure on the Immune System. Preprints 2024, 2024072321. https://doi.org/10.20944/preprints202407.2321.v1
Dąbrowska, A.; Wilczyński, B.; Mastalerz, J.; Kulbacka, J.; Szewczyk, A.; Rembiałkowska, N. The Impact of Liver Failure on the Immune System. Preprints2024, 2024072321. https://doi.org/10.20944/preprints202407.2321.v1
APA Style
Dąbrowska, A., Wilczyński, B., Mastalerz, J., Kulbacka, J., Szewczyk, A., & Rembiałkowska, N. (2024). The Impact of Liver Failure on the Immune System. Preprints. https://doi.org/10.20944/preprints202407.2321.v1
Chicago/Turabian Style
Dąbrowska, A., Anna Szewczyk and Nina Rembiałkowska. 2024 "The Impact of Liver Failure on the Immune System" Preprints. https://doi.org/10.20944/preprints202407.2321.v1
Abstract
Background: Liver failure profoundly affects the immune system, leading to dysregulation of innate and adaptive immune responses.
Body: This review explores the intricate relationship between liver function and immune homeostasis. The role of the liver as a central hub in immune response initiation is elucidated, emphasizing its involvement in hepatic inflammation induction and subsequent systemic inflammation. Cytokines, chemokines, growth factors, and lipid mediators orchestrate these immune processes, serving as both prognostic biomarkers and potential therapeutic targets in liver failure-associated immune dysregulation. Furthermore, the review delves into the mechanisms underlying immunosuppression in liver failure, encompassing alterations in innate immune cell functions such as neutrophils, macrophages, and natural killer cells (NK cells), as well as perturbations in adaptive immune responses mediated by B and T cells.
Conclusion: Understanding the immunological consequences of liver failure is crucial for developing targeted therapeutic interventions and improving patient outcomes in liver disease management.
Biology and Life Sciences, Cell and Developmental Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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