Tatti*, E.; Cinti, A.; Serbina, A.; Luciani, A.; D’Urso, G.; Cacciola, A.; Quartarone, A.; Ghilardi, M. F. Resting-State EEG Alterations of Practice-Related Spectral Activity and Connectivity Patterns in Depression. Preprints2024, 2024072337. https://doi.org/10.20944/preprints202407.2337.v1
APA Style
Tatti*, E., Cinti, A., Serbina, A., Luciani, A., D’Urso, G., Cacciola, A., Quartarone, A., & Ghilardi, M. F. (2024). Resting-State EEG Alterations of Practice-Related Spectral Activity and Connectivity Patterns in Depression. Preprints. https://doi.org/10.20944/preprints202407.2337.v1
Chicago/Turabian Style
Tatti*, E., Angelo Quartarone and Maria Felice Ghilardi. 2024 "Resting-State EEG Alterations of Practice-Related Spectral Activity and Connectivity Patterns in Depression" Preprints. https://doi.org/10.20944/preprints202407.2337.v1
Abstract
Background: Depression presents with altered energy regulation and neural plasticity. Previous electroencephalography (EEG) studies showed that practice increases power in beta range (13-30 Hz) in healthy subjects but not in those with impaired plasticity. Here, we ascertain whether depression presents with alterations of spectral activity and connectivity before and after practice. Methods: We used publicly available resting state EEG (64 electrodes) of 122 subjects. Based on Beck Depression Inventory (BDI) score, they were assigned to either high BDI (hBDI, BDI>13, N=46) or control (CTL, BDI<7, N=75) group. We analyzed spectral activity, theta-beta and theta-gamma phase-amplitude coupling (PAC) of EEG recorded before and after a learning task. Results: At baseline, compared to CTL, hBDI group exhibited greater beta power over fronto-parietal regions and gamma over right parieto-occipital area. After practice, increases in all frequency ranges were observed only in CTL. Theta-beta and theta-gamma PAC were greater in hBDI before the task but not after the task. Conclusions: The lack of substantial post-task growth of beta power in depressed subjects likely represents power saturation due to greater baseline values. We speculate that inhibitory/excitatory imbalance, altered plasticity mechanisms, and energy dysregulation present in depression may contribute to this phenomenon.
Keywords
Depression; EEG Oscillations; Fractal Dynamics; Phase-Amplitude Coupling; Resting State EEG; Beta frequency; Gamma frequency; Plasticity; Energy
Subject
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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