Version 1
: Received: 28 July 2024 / Approved: 30 July 2024 / Online: 31 July 2024 (07:42:29 CEST)
How to cite:
Karaglani, M.; Molla Moustafa, R.; Panagopoulou, M.; Chatzaki, E.; Drosos, G. Antibiotic Release and Mechanical Performance of PMMA Bone Cement: Findings from In Vitro Studies. Preprints2024, 2024072386. https://doi.org/10.20944/preprints202407.2386.v1
Karaglani, M.; Molla Moustafa, R.; Panagopoulou, M.; Chatzaki, E.; Drosos, G. Antibiotic Release and Mechanical Performance of PMMA Bone Cement: Findings from In Vitro Studies. Preprints 2024, 2024072386. https://doi.org/10.20944/preprints202407.2386.v1
Karaglani, M.; Molla Moustafa, R.; Panagopoulou, M.; Chatzaki, E.; Drosos, G. Antibiotic Release and Mechanical Performance of PMMA Bone Cement: Findings from In Vitro Studies. Preprints2024, 2024072386. https://doi.org/10.20944/preprints202407.2386.v1
APA Style
Karaglani, M., Molla Moustafa, R., Panagopoulou, M., Chatzaki, E., & Drosos, G. (2024). Antibiotic Release and Mechanical Performance of PMMA Bone Cement: Findings from In Vitro Studies. Preprints. https://doi.org/10.20944/preprints202407.2386.v1
Chicago/Turabian Style
Karaglani, M., Ekaterini Chatzaki and Georgios Drosos. 2024 "Antibiotic Release and Mechanical Performance of PMMA Bone Cement: Findings from In Vitro Studies" Preprints. https://doi.org/10.20944/preprints202407.2386.v1
Abstract
Using polymethylmethacrylate (PMMA) bone cement is widespread in orthopedic surgeries for implant fixation and as a carrier for antibiotic delivery to prevent and treat infections. This review comprehensively evaluates in vitro studies investigating the antibiotic elution profiles and mechanical properties of PMMA bone cement. We explore the kinetics of antibiotic release, factors influencing elution efficiency, and the impact of various antibiotics on the mechanical properties of PMMA composites. At the same time, we examine how the inclusion of antibiotics affects the mechanical integrity of PMMA, including parameters such as compressive strength, tensile strength, and fatigue resistance. Through a detailed analysis of these studies, this review aims to provide insights into optimizing PMMA bone cement formulations for enhanced therapeutic efficacy and structural performance.
Keywords
Polymethylmethacrylate; PMMA; bone cement; antibiotics; elution; mechanical; in vitro; additive; porogen; nanocomposite; gentamicin; vancomycin
Subject
Medicine and Pharmacology, Orthopedics and Sports Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
