Version 1
: Received: 28 July 2024 / Approved: 30 July 2024 / Online: 30 July 2024 (11:03:52 CEST)
How to cite:
Onchan, W.; Attakitbancha, C.; Uttamapinant, C. An Expanded Molecular and Systems Toolbox for Imaging, Mapping, and Controlling Local Translation. Preprints2024, 2024072413. https://doi.org/10.20944/preprints202407.2413.v1
Onchan, W.; Attakitbancha, C.; Uttamapinant, C. An Expanded Molecular and Systems Toolbox for Imaging, Mapping, and Controlling Local Translation. Preprints 2024, 2024072413. https://doi.org/10.20944/preprints202407.2413.v1
Onchan, W.; Attakitbancha, C.; Uttamapinant, C. An Expanded Molecular and Systems Toolbox for Imaging, Mapping, and Controlling Local Translation. Preprints2024, 2024072413. https://doi.org/10.20944/preprints202407.2413.v1
APA Style
Onchan, W., Attakitbancha, C., & Uttamapinant, C. (2024). An Expanded Molecular and Systems Toolbox for Imaging, Mapping, and Controlling Local Translation. Preprints. https://doi.org/10.20944/preprints202407.2413.v1
Chicago/Turabian Style
Onchan, W., Chadaporn Attakitbancha and Chayasith Uttamapinant. 2024 "An Expanded Molecular and Systems Toolbox for Imaging, Mapping, and Controlling Local Translation" Preprints. https://doi.org/10.20944/preprints202407.2413.v1
Abstract
Localized protein translation occurs through trafficking of mRNAs and protein translation machineries to different compartments of the cell, leading to rapid on-site synthesis of proteins in response to signaling cues. The spatiotemporally precise nature of the local translation process necessitates continual developments of technologies reviewed herein to visualize and map biomolecular components and the translation process with better spatial and temporal resolution, and with fewer artifacts. We also discuss approaches to control local translation, which can serve as a design paradigm for subcellular genetic devices for eukaryotic synthetic biology.
Keywords
local translation; translatome; ribosome; genetic code expansion; imaging
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
