Bridging the Gap: Understanding the Link between Blood Flow, Muscle Health, and Brain Function

Enzo Pereira de Lima; Masaru Tanaka; Caroline Barbalho Lamas; Karina Quesada; Claudia Rucco P. Detregiachi; Claudia Rucco P. Detregiachi; Adriano Cressoni Araújo; Virgínia Maria Cavallari Strozze Catharin; Marcela Vialogo Marques de Castro; Edgar Baldi Junior; Fidencio Rahal Ferraz; Vitor Cavallari Strozze Catharin; Lucas Fornari Laurindo; Sandra Maria Barbalho

doi:10.20944/preprints202407.2486.v1

Submit preprint
How it Works
Instructions for Authors
Subject Areas
Advisory Board
screening preprints
About
Awards
Log in/Register

Instructions for Authors
Awards
About
FAQ
Submit Log in/Register

Share this article with

Create alert

Email:

Load new image

preprints.org > medicine and pharmacology > psychiatry and mental health > doi: 10.20944/preprints202407.2486.v1 (registering DOI)

Preprint Review Version 1 This version is not peer-reviewed

Bridging the Gap: Understanding the Link between Blood Flow, Muscle Health, and Brain Function

Enzo Pereira de Lima

Masaru Tanaka

^* ,

Caroline Barbalho Lamas

Karina Quesada

Claudia Rucco P. Detregiachi

Adriano Cressoni Araújo

Virgínia Maria Cavallari Strozze Catharin

Marcela Vialogo Marques de Castro

Edgar Baldi Junior

Fidencio Rahal Ferraz

Vitor Cavallari Strozze Catharin

Lucas Fornari Laurindo

Sandra Maria Barbalho

Version 1 : Received: 29 July 2024 / Approved: 30 July 2024 / Online: 30 July 2024 (16:53:18 CEST)

How to cite: Lima, E. P. D.; Tanaka, M.; Lamas, C. B.; Quesada, K.; Detregiachi, C. R. P.; Detregiachi, C. R. P.; Araújo, A. C.; Catharin, V. M. C. S.; Castro, M. V. M. D.; Junior, E. B.; Ferraz, F. R.; Catharin, V. C. S.; Laurindo, L. F.; Barbalho, S. M. Bridging the Gap: Understanding the Link between Blood Flow, Muscle Health, and Brain Function. Preprints 2024, 2024072486. https://doi.org/10.20944/preprints202407.2486.v1 Lima, E. P. D.; Tanaka, M.; Lamas, C. B.; Quesada, K.; Detregiachi, C. R. P.; Detregiachi, C. R. P.; Araújo, A. C.; Catharin, V. M. C. S.; Castro, M. V. M. D.; Junior, E. B.; Ferraz, F. R.; Catharin, V. C. S.; Laurindo, L. F.; Barbalho, S. M. Bridging the Gap: Understanding the Link between Blood Flow, Muscle Health, and Brain Function. Preprints 2024, 2024072486. https://doi.org/10.20944/preprints202407.2486.v1

Cite

Export citation file: Bib TeX | RIS

MDPI and ACS Style

Lima, E. P. D.; Tanaka, M.; Lamas, C. B.; Quesada, K.; Detregiachi, C. R. P.; Detregiachi, C. R. P.; Araújo, A. C.; Catharin, V. M. C. S.; Castro, M. V. M. D.; Junior, E. B.; Ferraz, F. R.; Catharin, V. C. S.; Laurindo, L. F.; Barbalho, S. M. Bridging the Gap: Understanding the Link between Blood Flow, Muscle Health, and Brain Function. Preprints 2024, 2024072486. https://doi.org/10.20944/preprints202407.2486.v1

APA Style

Lima, E. P. D., Tanaka, M., Lamas, C. B., Quesada, K., Detregiachi, C. R. P., Detregiachi, C. R. P., Araújo, A. C., Catharin, V. M. C. S., Castro, M. V. M. D., Junior, E. B., Ferraz, F. R., Catharin, V. C. S., Laurindo, L. F., & Barbalho, S. M. (2024). Bridging the Gap: Understanding the Link between Blood Flow, Muscle Health, and Brain Function. Preprints. https://doi.org/10.20944/preprints202407.2486.v1

Chicago/Turabian Style

Lima, E. P. D., Lucas Fornari Laurindo and Sandra Maria Barbalho. 2024 "Bridging the Gap: Understanding the Link between Blood Flow, Muscle Health, and Brain Function" Preprints. https://doi.org/10.20944/preprints202407.2486.v1

Abstract

Vascular impairment, muscle atrophy, and cognitive decline are important age-related conditions that have a significant impact on health. Vascular impairment directly disrupts the flow of blood, leading to the decline of muscle mass associated with aging (sarcopenia) and the decline of neuronal functions (neurodegeneration). Our inadequate understanding of the complex relationships between these conditions impedes precise diagnosis and effective treatment. This review analyzes the interrelated mechanisms that contribute to these conditions, with a specific focus on oxidative stress, chronic inflammation, and impaired nutrient delivery. The aim is to understand the common pathways involved and to suggest comprehensive therapeutic approaches. Vascular dysfunctions hinder the circulation of blood and the transportation of nutrients, resulting in sarcopenia characterized by muscle atrophy and weakness. Vascular dysfunction and sarcopenia have a negative impact on physical function and quality of life. Neurodegenerative diseases exhibit comparable pathophysiological mechanisms that affect cognitive and motor functions. Preventive and therapeutic approaches encompass lifestyle adjustments, addressing oxidative stress, inflammation, and integrated therapies that focus on improving vascular and muscular well-being. Better understanding of these links can enhance therapeutic strategies and lead to better outcomes for patients. Here, we highlight the intricate relationship among vascular dysfunction, degenerative muscle, and cognitive decline, underscoring the need for multidisciplinary approaches to treatment. Progress in this field can result in improved diagnosis, more potent therapeutic options, and enhanced preventative measures, all of which can contribute to an improved quality of life for the aging population.

Keywords

vascular diseases; vascular atrophy; cognitive dysfunction; neurodegenerative diseases; oxidative stress; inflammation; aging; insulin resistance; nutrients; comorbidity

Subject

Medicine and Pharmacology, Psychiatry and Mental Health

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (0)

Not displayed online.

Importance: How significant is the paper to the field?

Outstanding/highlight paper

Significant contribution

Incremental contribution

No contribution

I am not qualified to judge

Soundness of evidence/arguments presented:

Conclusions well supported

Most conclusions supported (minor revision needed)

Incomplete evidence (major revision needed)

Hypothesis, unsupported conclusions, or proof-of-principle

I am not qualified to judge

Please leave your comment to this article below.

Mathematical equations can be typed in either LaTeX formats \\[ ... \\] or $$ ... $$, or MathML format <math> ... </math>. Try the LaTeX or MathML example.

Type equation:

Preview:

Copy equation into message below

Close menu

Please click a symbol to insert it into the message box below:

Please enter the link here:

Please enter a valid URL

Optionally, you can enter text that should appear as linked text:

Copy link into message below

Close menu

Please enter or paste the URL to the image here (please only use links to jpg/jpeg, png and gif images):

Please enter a valid URL

Copy image into message below

Close menu

Type author name or keywords to filter the list of references in this group (you can add a new citation under Bibliography):

No existing citations in Discussion Group

Wikify editor is a simple editor for wiki-style mark-up. It was written by MDPI for Sciforum in 2014. The rendering of the mark-up is based on Wiky.php with some tweaks. Rendering of mathematical equations is done with MathJax. Please send us a message for support or for reporting bugs.

Close menu

Please declare any conflicts of interest you may have with this paper, financial or otherwise.

I do not have a conflict of interest

I would like to declare a conflict of interest

Display my name on the website Send my name and email address to the authors

Captcha

Renew

I accept the following conditions:

Comments must follow the standards of professional discourse and should focus on the scientific content of the article. Insulting or offensive language, personal attacks and off-topic remarks will not be permitted. Comments must be written in English. Preprints reserves the right to remove comments without notice. Readers who post comments are obliged to declare any competing interests, financial or otherwise.

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)

* All users must log in before leaving a comment

what’s this?

Add a record of this review to Publons to track and showcase your reviewing expertise across the world’s journals.

Downloads 0

Comments 0

Metrics 0

Get PDF Cite Share 0

Bookmark BibSonomy Mendeley Reddit Delicious

Alerts

Notify me about updates to this article or when a peer-reviewed version is published.

Preprints.org is a free preprint server subsidized by MDPI in Basel, Switzerland.

MDPI Initiatives

SciProfiles
Sciforum
Encyclopedia
MDPI Books
Scilit
Proceedings
JAMS

Important links

How it Works
Advisory Board
FAQ
Friendly Journals
Instructions for Authors
About
Statistics

Choose the area that interest you and we will send you notifications of new preprints at your preferred frequency.

Disclaimer

We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.

RSS feed for

Preprints: The Multidisciplinary Preprint Platform

Paste the URL in your RSS reader:

https://www.preprints.org/rss

If you want to subscribe our website in subject-wide, you could find the URL by choosing in the following:

https://www.preprints.org/rss

Please note that by using ScienceDirect RSS feeds, you agree to our Terms of Use and Privacy Policy.