Preprint Article Version 1 This version is not peer-reviewed

Influence of Northern Wild Rice on Gut Dysbiosis and Short Chain Fatty Acids: Correlation with Metabolic and Inflammatory Markers in High Fat Diet-Induced Insulin Resistant Mice

Version 1 : Received: 29 July 2024 / Approved: 30 July 2024 / Online: 31 July 2024 (07:06:29 CEST)

How to cite: Zhao, R.; Fajardo, J.; Shen, G. X. Influence of Northern Wild Rice on Gut Dysbiosis and Short Chain Fatty Acids: Correlation with Metabolic and Inflammatory Markers in High Fat Diet-Induced Insulin Resistant Mice. Preprints 2024, 2024072490. https://doi.org/10.20944/preprints202407.2490.v1 Zhao, R.; Fajardo, J.; Shen, G. X. Influence of Northern Wild Rice on Gut Dysbiosis and Short Chain Fatty Acids: Correlation with Metabolic and Inflammatory Markers in High Fat Diet-Induced Insulin Resistant Mice. Preprints 2024, 2024072490. https://doi.org/10.20944/preprints202407.2490.v1

Abstract

The present study examined metabolites in Northern wild rice (WLD), the impact of WLD supplemented high fat (HF) diet on gut microbiota, short chain fatty acids (SCFAs) and correlation with metabolism or inflammation versus HF+white rice (WHR) in mice. C57BL/6J mice received HF diet supplemented with 26g% WHR, 26g% WLD, or 13g% WHR+13g% WLD (WTWD) for 12 weeks. The levels of fasting plasma glucose, total cholesterol, triglycerides, insulin resistance, inflammatory cytokines and monocyte adhesion were lower, and the abundances of fecal Lactobacillus gasseri species bacteria and propionic acid were higher in HF+WLD diet-fed mice compared to HF+WHR diet-fed mice (p

Keywords

wild rice; gut microbiota; short chain fatty acids; high fat diet; mice; metabolism; chronic inflammation; Lactobacillus gasseri; propionic acid

Subject

Biology and Life Sciences, Endocrinology and Metabolism

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