Version 1
: Received: 30 July 2024 / Approved: 31 July 2024 / Online: 31 July 2024 (11:07:43 CEST)
How to cite:
Spinello, I.; Labbaye, C.; Saulle, E. Metabolic function and Therapeutic Potential of CD147 for Hematological Malignancies: An Overview. Preprints2024, 2024072506. https://doi.org/10.20944/preprints202407.2506.v1
Spinello, I.; Labbaye, C.; Saulle, E. Metabolic function and Therapeutic Potential of CD147 for Hematological Malignancies: An Overview. Preprints 2024, 2024072506. https://doi.org/10.20944/preprints202407.2506.v1
Spinello, I.; Labbaye, C.; Saulle, E. Metabolic function and Therapeutic Potential of CD147 for Hematological Malignancies: An Overview. Preprints2024, 2024072506. https://doi.org/10.20944/preprints202407.2506.v1
APA Style
Spinello, I., Labbaye, C., & Saulle, E. (2024). Metabolic function and Therapeutic Potential of CD147 for Hematological Malignancies: An Overview. Preprints. https://doi.org/10.20944/preprints202407.2506.v1
Chicago/Turabian Style
Spinello, I., Catherine Labbaye and Ernestina Saulle. 2024 "Metabolic function and Therapeutic Potential of CD147 for Hematological Malignancies: An Overview" Preprints. https://doi.org/10.20944/preprints202407.2506.v1
Abstract
Hematological malignancies refer to a heterogeneous group of neoplastic conditions of lymphoid and hematopoietic tissues classified in leukemias, Hodgkin and non-Hodgkin lymphomas and multiple myeloma, according to their presumed cell of origin, genetic abnormalities, and clinical features.
Metabolic adaptation and immune escape, which influence various cellular functions including proliferation and survival of hematological malignant tumor cells, are major aspects of these malignancies that lead to therapeutic drug resistance. Targeting specific metabolic pathways is emerging as novel therapeutic strategy in hematopoietic neoplasms, particularly in acute myeloid leukemia and multiple myeloma. In this context, CD147, also known as Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) or Basigin, is one target-candidate involved in reprogramming metabolism in different cancer cells, including hematological malignant tumor cells. CD147 overexpression significantly contributes to the metabolic transformation of these cancer cells, by mediating signaling pathway, growth, metastasis and metabolic reprogramming, through its interaction, direct or not, with various membrane proteins related to metabolic, regulation including monocarboxylated transporters, integrins, P-glycoprotein and Glucose Transporter 1.
This review explores the metabolic functions of CD147 and its impact on the tumor microenvironment, influencing the progression and neoplastic transformation in leukemias, myeloma and lymphomas. Furthermore, we highlight new opportunities for the development of targeted therapies against CD147, potentially improving the treatment of hematologic malignancies.
Keywords
Hematological Malignancies, Metabolism, CD147.
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
