Version 1
: Received: 31 July 2024 / Approved: 1 August 2024 / Online: 1 August 2024 (11:04:16 CEST)
How to cite:
Mesilhy, R.; Nurulhaque, Z.; Burgon, P.; Pedersen, S.; Al Saady, R. Impact of Apolipoprotein A on Cardiac and Neural Abnormalities. Preprints2024, 2024080016. https://doi.org/10.20944/preprints202408.0016.v1
Mesilhy, R.; Nurulhaque, Z.; Burgon, P.; Pedersen, S.; Al Saady, R. Impact of Apolipoprotein A on Cardiac and Neural Abnormalities. Preprints 2024, 2024080016. https://doi.org/10.20944/preprints202408.0016.v1
Mesilhy, R.; Nurulhaque, Z.; Burgon, P.; Pedersen, S.; Al Saady, R. Impact of Apolipoprotein A on Cardiac and Neural Abnormalities. Preprints2024, 2024080016. https://doi.org/10.20944/preprints202408.0016.v1
APA Style
Mesilhy, R., Nurulhaque, Z., Burgon, P., Pedersen, S., & Al Saady, R. (2024). Impact of Apolipoprotein A on Cardiac and Neural Abnormalities. Preprints. https://doi.org/10.20944/preprints202408.0016.v1
Chicago/Turabian Style
Mesilhy, R., Shona Pedersen and Rafif Al Saady. 2024 "Impact of Apolipoprotein A on Cardiac and Neural Abnormalities" Preprints. https://doi.org/10.20944/preprints202408.0016.v1
Abstract
Apolipoprotein A (ApoA), an integral component of high-density lipoprotein (HDL) particles, plays a vital role in the transport and metabolism of lipids. It is implicated in both cardiovascular (CVD) and neurological diseases. In the context of CVD, ApoAs are pivotal in facilitating the reverse transport of cholesterol, mitigating inflammation, and preserving endothelial function. These char- acteristics highlight the crucial role of ApoA in averting the onset of CVDs. Moreover, ApoA has been implicated in the pathogenesis of several diseases, such as Alzheimer's disease (AD), Parkin- son's disease (PD), and multiple sclerosis (MS). Apart from its role in lipid metabolism, recent stud- ies have indicated the involvement of ApoA in neuroprotection, amyloid-beta clearance, and regu- lation of neuroinflammation. This paper addresses the research question: "How do different isoforms of Apolipoprotein A influence the development and progression of cardiovascular and neurological diseases, and what are the potential therapeutic implications of targeting ApoA in these conditions?" By providing a comprehensive review of current knowledge, this paper empha- sizes the importance of ApoA in understanding the intricate connections between cardiovascular and neurological health, suggesting that ApoA-targeted interventions may help treat diseases in both domains.
Medicine and Pharmacology, Cardiac and Cardiovascular Systems
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
