Version 1
: Received: 31 July 2024 / Approved: 1 August 2024 / Online: 1 August 2024 (14:07:39 CEST)
How to cite:
Giménez Orenga, K.; Martín-Martínez, E.; Oltra, E. Overrepresentation of TTMV9 in a Subgroup of Patients with ME/CFS. Preprints2024, 2024080073. https://doi.org/10.20944/preprints202408.0073.v1
Giménez Orenga, K.; Martín-Martínez, E.; Oltra, E. Overrepresentation of TTMV9 in a Subgroup of Patients with ME/CFS. Preprints 2024, 2024080073. https://doi.org/10.20944/preprints202408.0073.v1
Giménez Orenga, K.; Martín-Martínez, E.; Oltra, E. Overrepresentation of TTMV9 in a Subgroup of Patients with ME/CFS. Preprints2024, 2024080073. https://doi.org/10.20944/preprints202408.0073.v1
APA Style
Giménez Orenga, K., Martín-Martínez, E., & Oltra, E. (2024). Overrepresentation of TTMV9 in a Subgroup of Patients with ME/CFS. Preprints. https://doi.org/10.20944/preprints202408.0073.v1
Chicago/Turabian Style
Giménez Orenga, K., Eva Martín-Martínez and Elisa Oltra. 2024 "Overrepresentation of TTMV9 in a Subgroup of Patients with ME/CFS" Preprints. https://doi.org/10.20944/preprints202408.0073.v1
Abstract
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a chronic disorder classified by the WHO as postviral fatigue syndrome (ICD-11 8E49 code). Diagnosing ME/CFS, often overlapping with Fibromyalgia (FM), is challenging due to nonspecific symptoms and lack of biomarkers. The etiology of ME/CFS and FM is poorly understood, but evidence suggests viral infections play a critical role. This study employs microarray technology to quantitate viral RNA levels in immune cells from ME/CFS, FM, or co-diagnosed cases, and healthy controls. The results show significant overexpression of the Torque Teno Mini Virus 9 (TTMV9) in a subgroup of ME/CFS patients which correlate with abnormal HERV and immunological profiles. Increased levels of TTMV9 transcripts accurately discriminate this subgroup of ME/CFS patients from the other study groups, showcasing its potential as biomarker for patient stratification and the need for further research into its role in the disease.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
