Version 1
: Received: 30 July 2024 / Approved: 1 August 2024 / Online: 2 August 2024 (04:04:53 CEST)
How to cite:
BERTRAND, B.; HAFID, B.-T. Impact of Poly-L-Lysine Dendrimers on the Stability and Effectiveness of Vitamin C in Dermocosmetic Use. Preprints2024, 2024080078. https://doi.org/10.20944/preprints202408.0078.v1
BERTRAND, B.; HAFID, B.-T. Impact of Poly-L-Lysine Dendrimers on the Stability and Effectiveness of Vitamin C in Dermocosmetic Use. Preprints 2024, 2024080078. https://doi.org/10.20944/preprints202408.0078.v1
BERTRAND, B.; HAFID, B.-T. Impact of Poly-L-Lysine Dendrimers on the Stability and Effectiveness of Vitamin C in Dermocosmetic Use. Preprints2024, 2024080078. https://doi.org/10.20944/preprints202408.0078.v1
APA Style
BERTRAND, B., & HAFID, B. T. (2024). Impact of Poly-L-Lysine Dendrimers on the Stability and Effectiveness of Vitamin C in Dermocosmetic Use. Preprints. https://doi.org/10.20944/preprints202408.0078.v1
Chicago/Turabian Style
BERTRAND, B. and BELHADJ-TAHAR HAFID. 2024 "Impact of Poly-L-Lysine Dendrimers on the Stability and Effectiveness of Vitamin C in Dermocosmetic Use" Preprints. https://doi.org/10.20944/preprints202408.0078.v1
Abstract
Introduction:
This study explores the stabilization and efficacy enhancement of Vitamin C in dermocosmetic formulations through its association with Poly-L-lysine dendrimers. Vitamin C, critical for collagen synthesis and skin hydration, faces challenges due to its instability and low bioavailability. The research aims to evaluate the liposolubility of Vitamin C in the presence of Poly-L-lysine vectors, assess its stability in both aqueous and emulsion media, and determine the moisturizing efficacy of second-generation Poly-L-lysine (diameter: 4.5 nm, PM: 8.6 kDa) and third-generation Poly-L-lysine (diameter: 7 nm, PM: 22 kDa). Methods : Methods included high-performance liquid chromatography (HPLC) for concentration analysis, partition coefficient determination, and stability assessments under various conditions. Hydration potential and kinetics were evaluated on 11 volunteers using a corneometer.
Results: The liposolubility of Vitamin C increased by over 300% with Poly-L-lysine, enhancing its stability. Emulsion stability tests confirmed that formulations with Poly-L-lysine maintained their physical and chemical properties under stress conditions. Physiological tests showed significant improvements in skin hydration with the Poly-L-lysine/Vitamin C formulations, achieving 66.2% hydration increase at T3h for third-generation dendrimers.
Conclusion
In conclusion, Poly-L-lysine vectors significantly enhance the stability and moisturizing efficacy of Vitamin C in dermocosmetic formulations. These findings suggest that Poly-L-lysine can mitigate Vitamin C's instability and improve its dermocosmetic benefits, offering a promising approach for advanced skincare solutions.
Biology and Life Sciences, Biology and Biotechnology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
