Version 1
: Received: 1 August 2024 / Approved: 2 August 2024 / Online: 2 August 2024 (10:36:53 CEST)
How to cite:
Bejenaru, L. E.; Biţă, A.; Mogoşanu, G. D.; Segneanu, A.-E.; Radu, A.; Ciocîlteu, M. V.; Bejenaru, C. Polyphenols Investigation, Antioxidant and Anticholinesterase Activity of Rosmarinus officinalis L. Species from Southwest Romania Flora. Preprints2024, 2024080135. https://doi.org/10.20944/preprints202408.0135.v1
Bejenaru, L. E.; Biţă, A.; Mogoşanu, G. D.; Segneanu, A.-E.; Radu, A.; Ciocîlteu, M. V.; Bejenaru, C. Polyphenols Investigation, Antioxidant and Anticholinesterase Activity of Rosmarinus officinalis L. Species from Southwest Romania Flora. Preprints 2024, 2024080135. https://doi.org/10.20944/preprints202408.0135.v1
Bejenaru, L. E.; Biţă, A.; Mogoşanu, G. D.; Segneanu, A.-E.; Radu, A.; Ciocîlteu, M. V.; Bejenaru, C. Polyphenols Investigation, Antioxidant and Anticholinesterase Activity of Rosmarinus officinalis L. Species from Southwest Romania Flora. Preprints2024, 2024080135. https://doi.org/10.20944/preprints202408.0135.v1
APA Style
Bejenaru, L. E., Biţă, A., Mogoşanu, G. D., Segneanu, A. E., Radu, A., Ciocîlteu, M. V., & Bejenaru, C. (2024). Polyphenols Investigation, Antioxidant and Anticholinesterase Activity of <em>Rosmarinus officinalis</em> L. Species from Southwest Romania Flora. Preprints. https://doi.org/10.20944/preprints202408.0135.v1
Chicago/Turabian Style
Bejenaru, L. E., Maria Viorica Ciocîlteu and Cornelia Bejenaru. 2024 "Polyphenols Investigation, Antioxidant and Anticholinesterase Activity of <em>Rosmarinus officinalis</em> L. Species from Southwest Romania Flora" Preprints. https://doi.org/10.20944/preprints202408.0135.v1
Abstract
Rosemary is one of the most important medicinal plants for natural therapy due to its multiple pharmacological properties, such as antioxidant, anti-inflammatory, neuroprotective, antiproliferative, antitumor, hepato- and nephroprotective, hypolipidemic, hypocholesterolemic, antihypertensive, anti-ischemic, hypoglycemic, radioprotective, antimicrobial, antiviral, antiallergic, wound healing. Our study reports for the first time, over a 12-month period, the identification and quantification of polyphenols and the investigation of the antioxidant and acetylcholinesterase (AChE) inhibitory activity of the Rosmarinus officinalis L. species harvested at flowering from the flora of southwestern Romania (Oltenia Region). Identification and quantification of polyphenolic acids was made by ultra-high-performance liquid chromatography/mass spectrometry (UHPLC/MS). Total phenolic content was determined using the spectrophotometric method. In situ antioxidant and anticholinesterase activity was evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and AChE inhibitory assay, respectively, on high-performance thin-layer chromatography (HPTLC) plates. DPPH radical scavenging activity was also assessed spectrophotometrically. The results revealed significant correlations between specific polyphenolic compounds and the measured biological activities, understanding the role of seasonal variations and providing insights into the optimal harvesting times and medicinal benefits of rosemary. Our research brings new information on the phytochemical profile of R. officinalis, as a natural source of polyphenols with antioxidant and AChE inhibitory properties.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
