Review
Version 1
This version is not peer-reviewed
Beyond Transduction: Biological Effects of Cell Penetrating Peptides
Version 1
: Received: 1 August 2024 / Approved: 2 August 2024 / Online: 2 August 2024 (11:59:42 CEST)
How to cite: Lopuszynski, J.; Wang, J.; Zahid, M. Beyond Transduction: Biological Effects of Cell Penetrating Peptides. Preprints 2024, 2024080154. https://doi.org/10.20944/preprints202408.0154.v1 Lopuszynski, J.; Wang, J.; Zahid, M. Beyond Transduction: Biological Effects of Cell Penetrating Peptides. Preprints 2024, 2024080154. https://doi.org/10.20944/preprints202408.0154.v1
Abstract
One of the bottlenecks to bringing new therapies to the clinic has been a lack of vectors for delivering novel therapeutics in a targeted manner. Cell penetrating peptides (CPPs) have received a lot of attention and have been the subject of numerous developments since their identification nearly 3 decades ago. Known for their transduction abilities, they have generally been considered inert vectors. In this review we present a schema for their classification, highlight what is known about their mechanism of transduction, and outline the existing literature, as well as our own experience, vis a vis the intrinsic anti-inflammatory properties that certain CPPs exhibit. Given the inflammatory responses associated with viral vectors, CPPs represent a viable alternative to these vectors; further, the anti-inflammatory properties of CPPs, mostly through inhibition of the NF-κB pathway, are encouraging. Much work in relevant animal models, toxicity studies in large animal models, and ultimately human trials are needed before their potential is fully realized.
Keywords
Cell Penetrating Peptides; Inflammation; NF-κB; Protein Transduction Domains
Subject
Medicine and Pharmacology, Medicine and Pharmacology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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