Version 1
: Received: 5 August 2024 / Approved: 6 August 2024 / Online: 6 August 2024 (06:20:53 CEST)
How to cite:
Morabito, C.; Di Sinno, N.; Mariggiò, M. A.; Guarnieri, S. Impact of Extremely Low Frequency Electromagnetic Fields on Skeletal Muscle of Sedentary Adult Mice: A Pilot Study. Preprints2024, 2024080378. https://doi.org/10.20944/preprints202408.0378.v1
Morabito, C.; Di Sinno, N.; Mariggiò, M. A.; Guarnieri, S. Impact of Extremely Low Frequency Electromagnetic Fields on Skeletal Muscle of Sedentary Adult Mice: A Pilot Study. Preprints 2024, 2024080378. https://doi.org/10.20944/preprints202408.0378.v1
Morabito, C.; Di Sinno, N.; Mariggiò, M. A.; Guarnieri, S. Impact of Extremely Low Frequency Electromagnetic Fields on Skeletal Muscle of Sedentary Adult Mice: A Pilot Study. Preprints2024, 2024080378. https://doi.org/10.20944/preprints202408.0378.v1
APA Style
Morabito, C., Di Sinno, N., Mariggiò, M. A., & Guarnieri, S. (2024). Impact of Extremely Low Frequency Electromagnetic Fields on Skeletal Muscle of Sedentary Adult Mice: A Pilot Study. Preprints. https://doi.org/10.20944/preprints202408.0378.v1
Chicago/Turabian Style
Morabito, C., Maria A. Mariggiò and Simone Guarnieri. 2024 "Impact of Extremely Low Frequency Electromagnetic Fields on Skeletal Muscle of Sedentary Adult Mice: A Pilot Study" Preprints. https://doi.org/10.20944/preprints202408.0378.v1
Abstract
Extremely low-frequency electromagnetic fields (ELF-EMF) are ubiquitous in industrial-11 ized environments due to the continuous use of electrical devices. Our previous studies demon-12 strated ELF-EMF affects muscle cells by modulating oxidative stress and enhancing myo-genesis. 13 This pilot study investigated these effects on skeletal muscles of sedentary adult mice, assessing 14 physiological responses to ELF-EMF exposure and potential modulation by antioxidant supplemen-15 tation. Male C57BL/6 mice were exposed to ELF-EMF (0.1 or 1.0 mT) 1 hour/day up to 5 weeks, and 16 fed a standard diet without or with N-acetyl-cysteine (NAC). Results showed transient increases in 17 muscle strength (after 2-weeks’ exposure at 1.0 mT), potentially linked to muscle fiber recruitment 18 and activation, revealed by higher PAX7 and MyH expression levels. After ELF-EMF exposure, ox-19 idative status assessment revealed transient increases in expression levels of SOD1 and catalase en-20 zymes, in total antioxidant capacity and in protein carbonyl levels, marker of oxidative damage. 21 These effects were partially reduced by NAC. In conclusion, ELF-EMF exposure affects skeletal 22 muscle physiology and NAC supplementation partially mitigates these effects, highlighting the 23 complex interactions between ELF-EMF and antioxidant pathways in vivo. Further investigations 24 on ELF-EMF as a therapeutic modality for muscle health are necessary.
Copyright:
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