PreprintArticleVersion 1This version is not peer-reviewed
Enhancing Miconazole Anticancer Activity through Development of Drug in an Olive Oil-Based Nanoemulsion Formulations: A Promising Strategy Supported by Molecular Docking
Version 1
: Received: 6 August 2024 / Approved: 6 August 2024 / Online: 6 August 2024 (08:40:28 CEST)
How to cite:
Alamoudi, J. A.; Khafagy, E.-S.; Abu Lila, A. S.; Alqadhi, M. A.; Alotaibi, H. F. Enhancing Miconazole Anticancer Activity through Development of Drug in an Olive Oil-Based Nanoemulsion Formulations: A Promising Strategy Supported by Molecular Docking. Preprints2024, 2024080400. https://doi.org/10.20944/preprints202408.0400.v1
Alamoudi, J. A.; Khafagy, E.-S.; Abu Lila, A. S.; Alqadhi, M. A.; Alotaibi, H. F. Enhancing Miconazole Anticancer Activity through Development of Drug in an Olive Oil-Based Nanoemulsion Formulations: A Promising Strategy Supported by Molecular Docking. Preprints 2024, 2024080400. https://doi.org/10.20944/preprints202408.0400.v1
Alamoudi, J. A.; Khafagy, E.-S.; Abu Lila, A. S.; Alqadhi, M. A.; Alotaibi, H. F. Enhancing Miconazole Anticancer Activity through Development of Drug in an Olive Oil-Based Nanoemulsion Formulations: A Promising Strategy Supported by Molecular Docking. Preprints2024, 2024080400. https://doi.org/10.20944/preprints202408.0400.v1
APA Style
Alamoudi, J. A., Khafagy, E. S., Abu Lila, A. S., Alqadhi, M. A., & Alotaibi, H. F. (2024). Enhancing Miconazole Anticancer Activity through Development of Drug in an Olive Oil-Based Nanoemulsion Formulations: A Promising Strategy Supported by Molecular Docking. Preprints. https://doi.org/10.20944/preprints202408.0400.v1
Chicago/Turabian Style
Alamoudi, J. A., Mustafa A Alqadhi and Hadil Faris Alotaibi. 2024 "Enhancing Miconazole Anticancer Activity through Development of Drug in an Olive Oil-Based Nanoemulsion Formulations: A Promising Strategy Supported by Molecular Docking" Preprints. https://doi.org/10.20944/preprints202408.0400.v1
Abstract
We present a novel approach to repurpose the antifungal agent Miconazole as an anticancer therapeutic using olive oil-based nanoemulsion. The nanoemulsion exhibited a mean particle size of 177.76 ± 5.2 nm with a zeta potential of -24 ± 0.94 mV. Remarkably, Miconazole-loaded nanoemulsion displayed an IC50 of 1.4 ± 0.4 µg/ml against MCF-7 cells, while inducing apoptotic cell death by 70.31 ± 2.1%. In HePG2 and HCT 116 cells, IC50 values of 10.7 ± 1.2 and 5.9 ± 0.7 µg/ml were observed, respectively. These results demonstrate the promising anticancer potential of Miconazole-loaded olive oil nanoemulsion, highlighting its potential for repurposing Miconazole agents as effective anticancer therapeutics.
Public Health and Healthcare, Public Health and Health Services
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
