Version 1
: Received: 6 August 2024 / Approved: 7 August 2024 / Online: 7 August 2024 (14:09:47 CEST)
How to cite:
Boutin, C.; Clément, C.; Rivoal, J. Post-Translational Modifications of Cysteine Residues in Plant Proteins and Their Impact on the Regulation of Metabolism and Signal Transduction. Preprints2024, 2024080509. https://doi.org/10.20944/preprints202408.0509.v1
Boutin, C.; Clément, C.; Rivoal, J. Post-Translational Modifications of Cysteine Residues in Plant Proteins and Their Impact on the Regulation of Metabolism and Signal Transduction. Preprints 2024, 2024080509. https://doi.org/10.20944/preprints202408.0509.v1
Boutin, C.; Clément, C.; Rivoal, J. Post-Translational Modifications of Cysteine Residues in Plant Proteins and Their Impact on the Regulation of Metabolism and Signal Transduction. Preprints2024, 2024080509. https://doi.org/10.20944/preprints202408.0509.v1
APA Style
Boutin, C., Clément, C., & Rivoal, J. (2024). Post-Translational Modifications of Cysteine Residues in Plant Proteins and Their Impact on the Regulation of Metabolism and Signal Transduction. Preprints. https://doi.org/10.20944/preprints202408.0509.v1
Chicago/Turabian Style
Boutin, C., Camille Clément and Jean Rivoal. 2024 "Post-Translational Modifications of Cysteine Residues in Plant Proteins and Their Impact on the Regulation of Metabolism and Signal Transduction" Preprints. https://doi.org/10.20944/preprints202408.0509.v1
Abstract
Cys is one of the least abundant amino acids in proteins. However, it is often highly conserved and usually found in important structural and functional regions of proteins. Its unique chemical properties allow it to undergo several post-translational modifications, many of which mediated by reactive oxygen, nitrogen, sulfur or carbonyl species. Thus, in addition to their role in catalysis, protein stability and metal binding, Cys residues are crucial for redox regulation of metabolism and signal transduction. In this review, we discuss Cys post-translational modifications (PTMs) and their role in plant metabolism and signal transduction. These modifications include oxidation of the thiol group (S-sulfenylation, S-sulfinylation and S-sulfonylation), the formation of disulfide bridges, S-glutathionylation, persulfidation, S-cyanylation S-nitrosation, S-carbonylation, S-acylation, prenylation, CoAlation as well as the formation of thiohemiacetal. For each of these PTMs, we discuss the origin of the modifier, the mechanisms involved in PTM, as well as their reversibility. Examples of the involvement of Cys PTMs in the modulation of protein structure, function, stability, and localization are presented to highlight their importance in the regulation of plant metabolic and signaling pathways.
Keywords
post-translational modification; cysteine; regulation; signal transduction; metabolism; thiol; redox modification
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
