Review
Version 1
This version is not peer-reviewed
History and Toxinology of Palytoxins
Version 1
: Received: 1 August 2024 / Approved: 7 August 2024 / Online: 7 August 2024 (13:56:47 CEST)
How to cite: Roy, C.; Hammond, H. History and Toxinology of Palytoxins. Preprints 2024, 2024080522. https://doi.org/10.20944/preprints202408.0522.v1 Roy, C.; Hammond, H. History and Toxinology of Palytoxins. Preprints 2024, 2024080522. https://doi.org/10.20944/preprints202408.0522.v1
Abstract
Palytoxins are a group of highly potent and structurally complex marine biotoxins that rank among some of the most toxic substances known to science. Palytoxins are naturally synthesized by a variety of marine organisms, including Palythoa zoanthids, Ostreopsis dinoflagellates, and Trichodesmium cyanobacteria, and are widely distributed in tropical and temperate regions where they can bioaccumulate in marine life. The evolution of research on palytoxins has been an intricate exchange between interdisciplinary fields, drawing insights from chemistry, biology, medicine, and environmental science in efforts to better understand and mitigate the health risks associated with this family of toxins. In this review, we begin with a brief history covering the discovery of this group of toxins and the events that led to its isolation. We then focus on the chemical structure of these compounds and their proposed mechanism of action. Finally, we review in vitro and in vivo studies related to their toxicity, with the aim to provide a broad overview of the current knowledge on palytoxin toxicology.
Keywords
palytoxin; ovatoxin; zoanthids; aerosol; inhalation; disease models
Subject
Medicine and Pharmacology, Pharmacology and Toxicology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Comments (0)
We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.
Leave a public commentSend a private comment to the author(s)
* All users must log in before leaving a comment